Starter Activity: On a show me board, write down the explanation of “denatured”.

1. Starter Activity: On a show me board, write down the explanation of “denatured”. You could also include examples of when an enzyme may become denatured.

2. Key Area 6 Genetic Engineering

3. Genetic Engineering Learning Intention: We are learning the process of genetic engineering. Success Criteria: Be able to name two hormones made by genetic engineering. Be able to describe the genetic engineering Process. Be able to state the meaning of a genetically modified organism.

4. Insulin Diabetics cannot produce insulin. This means that they cannot control the level of glucose in their blood They used to inject insulin that came from cows and pigs.

5. Problem with that . . . • 1. It was a slow and expensive process • 2. Some people were allergic to the animal insulin • 3. Some people did not like the idea of injecting a substance that came from animals

6. Genetic Engineering E.g. Human to bacteria Genetic engineering is the transfer of genetic material from one organism to another

7. Genetic Engineering • This process can be used to get the second organism to produce a specific protein e.g.. Insulin or Human Growth Hormone • Bacteria are often used because their plasmids are easy to remove, alter and replace. • A plasmid is a ring of DNA found in bacteria that is used in genetic engineering.

8. plasmids bacterium gene circular chromosome

9. Plasmid removed from a bacterium Part of human chromosome Plasmid cut open Gene for insulin cut out of chromosome Gene inserted into plasmid Plasmid inserted into bacterium Large circular chromosome

10. Genetic Engineering • The bacteria will multiply. • The hormone can then be extracted and purified. • The bacterium is now an organism that has been genetically modified.

11. Genetic Engineering Learning Intention: We are learning the process of genetic engineering Success Criteria: Be able to name two hormones made by genetic engineering Be able to describe the genetic engineering process Be able to state the meaning of a genetically modified organism

12. Starter Activity: Answer the following in sentences in the back of your notebook: Name two hormones made by genetic engineering Name the structure removed from bacteria that the required gene is inserted into Give a description of the genetic engineering process

13. Genetic Engineering Learning Intention: We are learning the advantages and disadvantages of genetic engineering Success Criteria: Be able to describe the advantages and disadvantages of genetic engineering. Be able to demonstrate the process of genetic engineering using modelling clay and card.

14. Advantages of Genetic Engineering • Single characteristic can be selected. • Increased range of products. • Very quick. • Increased product purity. • Characteristic can be transferred from one organism to another.

15. Disadvantages of Genetic Engineering • Risk of release of genetically engineered bacteria into environment. • Cost of development is expensive. • Transfer of antibiotic resistance.

16. Task • Using the resources provided by your teacher, try to describe the process of genetic engineering to your partner.

17. Watch and Listen • Video Clip

18. Natural Genetic Engineers • DNA can be transferred naturally between cells either by bacterial plasmids or viruses.

19. Homework • You must research a genetically modified organism and present your findings to the rest of your class in PowerPoint or Poster format. • Power Points should be 5-7 slides long • Posters must be at least A3 size

20. Genetic Engineering Learning Intention: We are learning the advantages and disadvantages of genetic engineering Success Criteria: Be able to describe the advantages and disadvantages of genetic engineering Be able to demonstrate the process of genetic engineering using modelling clay and straws

21. Lights, Camera, Action! Your task… Plan and produce a training video or instruction manual (as a leaflet) for scientists carrying out genetic engineering of bacteria to make human insulin. Assessment criteria: Your clip or leaflet must: • Be at least 2 minutes/1 side of A4. • Describe what genetic engineering is. Your clip or leaflet should: • Explain the process of genetic engineering using bacteria to make human insulin. • Use resources to model the process. Your clip or leaflet could… • Describe any safety precautions the scientists must use. • Describe the advantages of genetic engineering. • Describe the disadvantages of genetic engineering.

22. You should carry out research on an area of biology ,from Key Area 1.6 (your teacher can help with this). You should gather research on the background of the application you are investigating and impact it has on the environment and society. This research can be taken into class and used to help you write your report. During your first period back, your teacher will ask you to write your report, in class. It should be between 50 and 100 words and include: 1. A description and the biology involved in the chosen application being investigated. 2. The impact it has on the environment or society. 3. Your references. Collect a green slip & glue it into your planner: Holiday HomeworkPreparation for Short Research Report

23. Topics for Research Report • Research current genetic foods/issues such as golden rice • less toxic rape seed oil • bird resistance to bird flu • tomatoes with longer shelf life • blight resistant potatoes • production of medicines for human use

24. Your first tasks: • Read over your research information and write a brief summary on a show me board. • In pairs describe the following to each other: the underlying biology of the application being investigated and impact of the application on the environment and/or society. • In the back of your notebook write a bullet point plan for your short research report.

25. Genetic Engineering: Your topic Unit 1 Key Area 6: Genetic Engineering.

26. List the sources you used to find your information.

27. Once your report has been marked you may be asked some extra questions. You will only be asked extra questions if there isn’t enough information in your report to fully explain the background information or impact of your application.