1 / 48

Norrish Type I Cleavage

Fortner, Kevin C.; Kato, Darryl; Tanaka, Yoshiki ; Shair , Matthew D. Enantioselective Synthesis of (+)- Cephalostatin 1. Journal of the American Chemical Society (2010), 132(1), 275-280. . Norrish Type I Cleavage. The Alder Ene Reaction. Examples of Ene Reactions.

marcie
Download Presentation

Norrish Type I Cleavage

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Fortner, Kevin C.; Kato, Darryl; Tanaka, Yoshiki; Shair, Matthew D. Enantioselective Synthesis of (+)-Cephalostatin 1. Journal of the American Chemical Society (2010), 132(1), 275-280.

  2. Norrish Type I Cleavage

  3. The Alder Ene Reaction

  4. Examples of Ene Reactions

  5. PPTS = pyridium p-toluenesulfonate =

  6. The Marker Degradation The Marker Degradation allowed the production of steroids, such as sex hormones, from plant steroids, readily available in large quantities. This allowed the production of oral contraceptives, and was a catalyst for the development of the Mexican chemical industry.

  7. Reagents which result in an ‘activated’ form of DMSO

  8. MukaiyamaAldol Addition

  9. Mechanism of the MukaiyamaAldol Addition

  10. HDTC = Hydrazinedithiocarbonate =

  11. The Mitsunobu Reaction The Mitsunobu Reaction involves an Sn2 type substitution, thus occurs with inversion of configuration

  12. Mechanism of the Mitsunobu Reaction

More Related