1 / 21

PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine

PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine. Reporter: Fei Liu Supervisor: Prof. Zhi Yang 31 March 2014 Mentor: Nan Li and Hua Zhu. Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55. PET Imaging of Glutaminolysis in Tumors by 18F-(2S,4R)4-Fluoroglutamine.

marcus
Download Presentation

PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. PET Imaging of Glutaminolysis in Tumors by 18F-(2S,4R)4-Fluoroglutamine Reporter: Fei Liu Supervisor: Prof. Zhi Yang 31 March 2014 Mentor: Nan Li and Hua Zhu Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

  2. PET Imaging of Glutaminolysis in Tumors by 18F-(2S,4R)4-Fluoroglutamine Reporter: Fei Liu Supervisor: Prof. Zhi Yang 31 March 2014 Mentor: Nan Li and Hua Zhu Contents:

  3. Contents: Contents: PET Imaging of Glutaminolysis in Tumors by 18F-(2S,4R)4-Fluoroglutamine Reporter: Fei Liu Supervisor: Prof. Zhi Yang 31 March 2014 Mentor: Nan Li and Hua Zhu Contents:

  4. 1 2 3 4 Contents: Background Research Summary Development

  5. 1 2 3 4 Contents: Background Research Summary Development

  6. 1 Background

  7. 1 2 3 4 Contents: Background Research Summary Development

  8. 2 Research Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

  9. 2 Research Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

  10. 2 Research Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

  11. 2 Research Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

  12. 2 Research Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

  13. 2 Research Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

  14. 2 Research Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

  15. 1 2 3 4 Contents: Background Research Summary Development

  16. 3 In vitro tumor cell uptake of 18F-(2S,4R)4-Fluoroglutamine is higer than uptake of 18F-FDG. 1 Summary In vivo PET studies showed significant tumor uptake adnd trapping inside tumor tissue in 2 different tuor models. 2 The results support the feasibility of PET for the study of a fundamental change in tumor metabolism---high-rate glutaminolysis. 3

  17. 1 2 3 4 Contents: Background Research Summary Development

  18. 4 Development Kung HF，et al, Chemistry. Science, 2013 , 342(6157):429-30.

  19. 4 Development

  20. THANK YOU T

  21. Q&A

More Related