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Background

Interdisciplinary Research Stimulating Health Technology Innovation in IMSaT Dr Mike MacDonald IMSaT and Physics University of Dundee 23 April 2010. Background. IMSaT.

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  1. Interdisciplinary Research Stimulating Health Technology Innovation in IMSaTDr Mike MacDonaldIMSaT and Physics University of Dundee23 April 2010

  2. Background

  3. IMSaT • Institute for Medical Science and Technology (IMSaT) launched in January2008 by University ofDundee to promote joint activitybetween medicine, life sciences andthe physicalsciences andengineering LifeSciences IMSaT Medicine Science and Engineering

  4. IMSaT • Institute for Medical Science and Technology (IMSaT) launched in January2008 by University ofDundee to promote joint activitybetween medicine, life sciences andthe physicalsciences andengineering LifeSciences IMSaT Medicine Science and Engineering

  5. Realisation Ninewells Hospital • More than £6M investment • More than £17M awards since launch • Now ~50 staff and students • Facilities almost completed IMSaT

  6. Facilities

  7. Local Laboratories • Cell biology and nanomedicine • Interventional MRI • Surgical Technology • Photonics • Ultrasonics IMSaT Infrastructure

  8. Local Laboratories • Cell biology and nanomedicine • Interventional MRI • Surgical Technology • Photonics • Ultrasonics IMSaT Infrastructure

  9. Local Laboratories • Cell biology and nanomedicine • Interventional MRI • Surgical Technology • Photonics • Ultrasonics IMSaT Infrastructure

  10. Staff and Collaborators

  11. IMSaT Research Leaders • Prof. Andreas Melzer, Director, specialism in MRI-guided intervention and surgery • Prof. Sir Alfred Cuschieri, Chief Scientific Advisor, specialism in minimal access surgery • Dr Sandy Cochran, Team Leader in medical ultrasound • Dr Stuart Brown, Team Leader in surgical technology • Dr Mike MacDonald, Team Leader in biophotonics • Dr Paul Prentice, Team Leader in photoacoustics • Dr Lijun Wang, Team Leader in cell biology and nanomedicine

  12. Research Leader Backgrounds • Andreas Melzer – pre-clinical • Alfred Cuschieri – clinician/scientist • Sandy Cochran – engineer / physicist • Stuart Brown – mechanical engineer • Mike MacDonald – applied physicist • Paul Prentice – applied physicist • Lijun Wang – life scientist • TBC – clinician • TBC – life scientist

  13. Some Local Collaborators • Prof. Alistair Thomson, Surgery and Molecular Oncology, Ninewells Hospital • Dr George Corner, Medical Physics/Ultrasound, Ninewells Hospital • Dr Elaine Henry, Gastroenterology, Ninewells Hospital • Dr Graeme Houston, Oncology, Ninewells Hospital • Dr Zhihong Huang, Ultrasound, Dundee University • Dr Rob Keatch, Tissue Engineering, Dundee Univ. • Dr Graeme MacLeod, Anaesthesia, Ninewells Hospital

  14. Some External Collaborators • University of Birmingham, Materials • University of Bristol, Mechanical Engineering • Fraunhofer IKTS, Materials • University of Glasgow, Electronic Engineering • Institute for Cancer Research, Medical Physics • Insightec (Israel), Focused ultrasound surgery • Penn State University, Materials • University of Southampton, Engineering • Trondheim University, Surgical technology • Weidlinger Associates (USA), Design software

  15. Some Previous/Present Collaboration

  16. Strategy and Delivery

  17. Strategic Dimensions • Key Target Area Image-guided intervention • Applications Oncology, Cardiovascular, and Other (e.g. Anaesthesia, Surgical techniques) • Technology MRI, ultrasound, and biophotonic imaging, with state-of-the-art intervention, including surgical technology and devices • Collaboration Strong bias towards scientific, engineering and clinical collaboration • Clinical application Strong bias towards clinical application of research outcomes

  18. IMSaT’s strategic plan includes a project pipelinefor commercialisation of research Commercialisation

  19. Large Projects • Nanoporation (£1.8M) – Targeted drug delivery • Sonotweezers (£1.5M) – Particle / cell manipulation • Lightsheet microscopy (£0.7M) – embryo imaging • Biomag (£1.4M) – Surgical manipulation of magnetised tissue • Laparoscopy (£2.5M) – New tools for keyhole surgery • IIIOS (£3.7M) – Interventional imaging operating system • DPFS (£0.6M) - Device / model development

  20. Sample of Other Projects • Ultrasonic virtual histology (3 x grad student) • Devices for ultrasonic cutting (3 x grad student) • Integration of Si and piezoelectrics (1 x postdoc) • Ultrasound guided regional anaesthesia(2 x grad student, 1 x undergrad) • Laser generated ultrasound (1 x grad student) • Photoacoustic imaging (1 x grad student) • Optical anastamotic perfusion assessment (1 x ungrad) • MRgFUS (4 x grad student) • Tissue motion tracking (2 x grad student) • Microbubble processing (1 x grad student) • Nerve regeneration with magnetic nanoparticles (1 x postdoc) • Organ retraction in surgery (1 x postdoc) • Ultrasound phantoms (1 x postdoc)

  21. Case Study: MRgFUS

  22. MRgFUS: MRI-guided Focused Ultrasound Surgery • Risks of surgical therapy outweigh potential benefits for many patients • E.g. frail, elderly patients and patients with benign tumours • Non-invasive focused ultrasound surgery is a possibility • Image guidance is crucial

  23. Simple Ultrasonic Hyperthermia Custom transducer for high intensity focused ultrasound (HIFU) Hyperthermia applied to poultry breast in vitro, max. intensity 240 W cm-2

  24. Illustrative Results HFUS Visual Histology SEM

  25. Illustrative Results HFUS Necrosed tissue Viable tissue Visual Histology SEM

  26. Image Guidance • MRI presently the leading image guidance technique • MRgFUS - MRI-guided focused ultrasound surgery • Ultrasound guidance also possible

  27. MRgFUS Thiel cadaver with InSightec Exablate 2000 system

  28. Matrix Array Transducer • Preliminary trials of hyperthermic necrosis of cadaveric liver

  29. Robot-mounted Matrix Array • Demonstration of possible future of image-guided surgery

  30. Summary and the Future

  31. Summary • IMSaT and its partners now allow seamless translation of basic research into clinical progress • Imaging is a key topic in Dundee • Many projects now under way • Case study: MR-guided focused ultrasound surgery • Great potential; many major companies and universities engaged in clinical studies

  32. Next Steps • Stronger theming Less opportunistic funding, stronger focus on strategy • Commercialisation Recruitment of business liaison person • Enhanced marketing/sales Revised website, planned exhibition and conference attendance • ISO13485/GLP Certification To reduce barriers to clinical adoption • Additional facilities Establishment of full preclinical resource unit

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