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Crook Disc Prognosis

Crook Disc Prognosis. (Or what’s worth observing) By Dr David McGrath . Pre 1997 State of Affairs. Biological Variables: Duration of Pain, Past Hx of Pain, Leg Pain, BMI, (Disability)

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Crook Disc Prognosis

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  1. Crook Disc Prognosis (Or what’s worth observing) By Dr David McGrath

  2. Pre 1997 State of Affairs • Biological Variables: Duration of Pain, Past Hx of Pain, Leg Pain, BMI, (Disability) • Psychosocial Variables: Education, MMPI, Sickness Impact score, Depression, Coping level, Distress, Fear • Work Variables: Job Satisfaction, Work Capacity.

  3. Fear- Avoidance Model • Intolerance of activity may not be a biological factor but instead have a substantial behavioural basis • Activity intolerance can be explained by a combination of pain severity, depression and illness behaviour • Fear avoidance can lead to chronicity • Basis for cognitive /behavioural Rx

  4. Epidemiological Shortcomings • The results of a survey will be a function of the questions asked • More reliable studies include a large number of variables then submit them to multiple regression analysis • Longitudinal studies are best

  5. Medline Searches 1999-2005 • LBP • LBP + Natural History • IDD + Natural History • LBP + Disc Prolapse • LBP + Prognostic

  6. Ascending Chronological Order • No judgement about quality of study, only if they seem to address prognostic indicators • Individual studies and literature reviews

  7. 1999 Far-Lateral Disc Herniations • N=16 • Radicular Pain (concordant with root) • 3 year study • 71 % Full recovery with no surgery • Ref (1)

  8. 1999 VEP # Hypothesis • Common Cause of BP is vertebral end plate fracture • “ natural history” of BP consistent with hypothesis • Ref 2

  9. 2000 Relation between Intensity, Disability, Recurrence of LBP • N=94 • Disability +ve correlates with pain intensity • Episodic nature of painful periods -ve correlates with functionality at work and home • “Not a static phenomenon” • Ref (3)

  10. 2000 Exercise Rx and Outcome post Discectomy • N=20 • Exercise vs normal activities • 4 week exercise program • Improvements in pain, spinal ROM, disability score over non exercise group • Maintained at 1 year • Ref(4)

  11. 2000 N/H Asymptomatic Disc MRI • N=46 • 5 year follow up • No change to herniations or neural compression • “Disc degeneration” progressed in N=17 • Minor episodes of LBP in N=19 • 5 of 19 obtained Sick Leave • 5 S/L best predicted by job characteristics and job satisfaction and NOT MRI • Ref(5)

  12. 2000 Herniated Discs • N/H of nucleus pulposus herniations complex with variables such as inflammation, compression and pain altering prognosis • Relationship between Imaging and LBP or radiculopathy not clear • “Value” of MRI may be monitoring changes in longitudinal studies • Ref (6)

  13. 2000 Prospective LBP Study • N=1455 • Questionairre blind survey to adults • 1/3 lifetime NO LBP • 4% year new incidence rate • 40% intermittent LBP • Ref (7)

  14. 2000 Socioeconomic aspects MRI • MRI facilitates “medicalization” of LBP • Urging radiologists to avoid unnecessary labelling possibly leading to inappropriate treatment • Ref (8)

  15. 2000 Surgery Disc Prolapse • Cochrane Review up to 31/12/99 • N=27 trials • Surgical discectomy provides faster relief from acute attack than conservative management but +ve or –ve effects on lifetime natural history is unclear • Chemonucleolysis better than placebo but worse than surgery • All surgery similar results • Ref (9)

  16. 2002 N/H Sequestrated Disc Herniation • N=49 • Signal Intensity on T2 of herniation compared to nucleus pulposus is indicator of potential for herniation reduction with time • Ratio of intensities >1.2 predictive • Ref(10)

  17. 2002 N/H Disc Herniation with Radiculopathy • “Majority” of patients suffering radiculopathy (Herniated NP) resolve spontaneously without surgery or chemonucleolysis • Ref(11)

  18. 2002 LBP General Population • Population of 17,000 • 2 year follow up of LBP patients • No predictive factors for recovery • 2% per year new LBP event • LBP often becomes chronic even when sick leave is rare • Ref(12)

  19. 2002 N/H & Risk Factors Musculoskeletal Conditions US Army • N=15268 • LBP conditions greatest risk of disability • Male Risk Factors: low pay, diagnosis, shorter length service, older, occ category, lower job satisfaction, smoking, work stress, physical demands. • Female Risk: Lower Educational level • Ref(13)

  20. 2003 N/H Spodylolysis & Spondylolithesis • N=30 from a population of 500 • Inception ages 6-30 • 45 year follow up • Unilateral defects NO slippage • Progression of slip slowed with decades • No association slip and pain • Pain and disability scores same as age cohort • Ref(14)

  21. 2003 GP perceptions of LBP • Straightforward condition or complicated? • Frustration with those that fail to recover • Biomechanistic approach and good N/H works well for most • Psychological and social dimensions? • Ref(15)

  22. 2003 N/H of Aging Spine • Multiple structural changes • “unrelenting changes leading to scoliosis, destabilisation, and rupture of equilibrium” • Ref(16)

  23. 2003 Risk factors for progression of disc degeneration • N=796 • Mean age of cohort 54 • Mean BMI 25 • Anterior osteophytes (AO) and disc narrowing (DSN) • AO Progression correlates with age, radiographic OA of hip. • DSN progression correlates age, BP, radiographic AO hip and knee • Nil significance for smoking, physical activity, other • Ref(17)

  24. 2003 Acute LBP Prognosis • Literature review • Most people recover rapidly • Recurrence common • Ref(25)

  25. 2003 LBP Prognosis post MVA • N=4473 • Change in legal entitlement with no common law claims • Claim closure faster • Higher pain, slower claim closure • Ref(26)

  26. 2003 Prognosis Subacute LBP • N=164 Working group • Duration pain 4-12 weeks • Predictors, age and pain intensity • Type of work, not work satisfaction predictive • Ref(30)

  27. 2004 Management Chronic LBP • Opinion • Monotherapies. Either don’t work or limited efficacy • Multidisciplinary based on intensive exercises. Improves physical function and has modest effects on pain. • Reductionism. Pathoanatomical diagnosis. Treatments are emerging for Z, disc,S/I joints. • Ref(18)

  28. 2004 N/H and prognostic indicators of sciatica • N=622 Workers electricity/gas • Follow up 2 years • Factors predictive of persistence or recurrence were: driving at least 2 hours per day, carrying heavy loads at work, a high level of psychosomatic problems, and pain preceeding onset of study. • Ref (19)

  29. 2004 Dutch Army “minimal intervention” LBP • “minimal sports medicine approach” • 2 short training sessions per week • Study in progress • Ref(27)

  30. 2004 Prognostic Factors Recurrent BP • Prospective cohort, factory Holland • Prognostic factors, high disability and to a lesser degree job satisfaction, low decision authority, low social support. • Ref(28)

  31. 2004 Scaffolders LBP • N=288 3 year Questionnaire study • 20% pain every year. 26% nil pain every year. • High rate of BP incidence, recurrence and recovery • High association of cumulative recurrence with manual handling, high job demands, low job control • Weak association with BMI, general health • Ref(20)

  32. 2004 Quality of Life Prognostic Indicator of Acute LBP • N=113 • 5% developed chronic LBP • Delayed recovery with compensation status, initial disability, lower SF-36 (quality of life) • Lower SF-36 with psychiatric disorders, unemployed, comorbidity, job dissatisfaction, foreign origin. • Ref(21)

  33. 2004 LBP Diagnosis, Rx, Prognosis • Rx’s mostly pain modulating, not cure • N/H favourable • A worry is long term disabled • Fear avoidance behaviour part of disabling pathway • Removing fear and uncertainty. The back is “robust even if it hurts”. Promising approach. • Ref(22)

  34. 2004 Outcomes with peri-radicular infiltration, disc herniation • N=55 Radicular pain • Mean change VAS 2 • 3 month follow up • N/H or treatment effect? • Ref(23)

  35. 2004 Fear Avoidance Validation LBP • N=388 • Assessment 6 months post treatment • Fear avoidance score predictive of chronicity • Ref(31)

  36. 2004 Ergonomic Interventions LBP • N=1631 • “ergonomic Interventions are Successful” • Ref(32)

  37. 2004 LBP Outcomes Longitudinal Study • N=? • 1 year follow up • 75 % continuing symptoms • Baseline pain and general health predicitive of continuing BP • Work satisfaction and negative event predictive of pain and disability • Ref(24)

  38. 2004 LBP in young NZers • N=969 Birth cohort age26 • LB data questionnaire. BP previous year. • 54% LBP previous one year with 3-4 times a episodes year • N=448 working. No difference between professional, clerical, technical, trade or production. N=56 required S/L • N=13 unable to care for themselves • Ref (25)

  39. 2004 Prolotherapy • Systematic Review • 4 trials high quality • Conclusions confounded by clinical heterogeneity and co-interventions • No evidence that prolotherapy alone more effective than control injections. • Ref(26)

  40. 2004 RTW LBP Prognosis • Literature Review • Prognostic Factors: P/H of LBP, low level job satisfaction, poor general health • Other factors such as wage, compo, depression, physical factors, work postures less significant • Ref(35)

  41. 2004 Prognosis Lumber Discectomy • N=48 • Poor outcome predicted by reduced SLR, depression • Ref(36)

  42. 2004 Prognostic Value of Functional Capacity Evaluation • N=226 • Validity of Functional Capacity assessments “suspect” • Ref(33)

  43. 2004 Back Schools LBP • Literature search • Content of schools has changed • Moderate evidence schools in occupational setting reduce pain, improve function and RTW status cf to Other treatments. • Ref(27)

  44. 2004 McKenzie • Systematic Review 6 trials • Better results than Other for LBP with short term pain/disability • No trials for McKenzie vs placebo • Insufficient data for neck pain • Ref(28)

  45. 2005 Questionnaires. What do they assess • Main focus on activity limitations • Considerable variation • Only a few could be considered acceptably validated using WHO criteria • Ref(29)

  46. 2005 Behavioural treatment for chronic LBP • Cochrane database • Better than waiting list in short term • No significant difference between behavioural and exercise • No conclusions or recommendations can be made from this data • Ref(30)

  47. 2005 Multidisciplinary Rehab Prognosis • N=? • Predictive of poor outcome was number of pre admission health care visits • Ref(37)

  48. 2005 Acupuncture LBP • Cochrane data base • Data does not allow firm conclusions for acute LBP • For chronic LBP better than nil Rx immediately after Rx and short term • No more effective than other Rx • Data suggests useful adjunct to other Rx • Ref(31)

  49. Conclusions 2005 • Biological variables continue to have predictive power. In particular Intensity of pain and previous episodes. • Probably lack of diagnostic precision hampers further progress. Imaging findings have poor predictive capacity as they distinguish structural pathology NOT painful pathology. Precision needle techniques are often used as therapeutic interventions. • Spinal physiology needs improving.

  50. Conclusions 2005 (contd) • BP tends to be a recurring problem. We do not know why. The structural limits of a component are probably exceeded during flare ups. Adaptive changes such as tissue remodelling may be overwhelmed in the short term or longer. • Ability is a multi-dimensional concept of interaction. Any of these variables can have a feedback influence on a vulnerable structure through spinal and neural dynamics.

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