1 / 8

INTERGROUP COLLABORATION AGAINST SARCOMAS (ICAS) FOCUS

INTERGROUP COLLABORATION AGAINST SARCOMAS (ICAS) FOCUS. Biologically targeted therapeutics Histology specific Facilitate Intergroup Collaboration. Growth Factor Receptor Expression in Sarcomas. Sarcoma EGF-R* PDGF-R** MPNST 7/7 † -- Synovial Cell* 17/25 0/2

marietta-anglim
Download Presentation

INTERGROUP COLLABORATION AGAINST SARCOMAS (ICAS) FOCUS

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. INTERGROUP COLLABORATION AGAINST SARCOMAS (ICAS)FOCUS • Biologically targeted therapeutics • Histology specific • Facilitate Intergroup Collaboration

  2. Growth Factor Receptor Expression in Sarcomas Sarcoma EGF-R* PDGF-R** MPNST 7/7 † -- Synovial Cell* 17/25 0/2 Fibrosarcoma 8/11 -- MFH 12/17 11/12 Liposarcoma -- 9/12 Leiomyosarcoma -- 3/7 *Common (70%) SSX1 translocation: Her2 21/32 Her4 12/13 †JCI 105:1233 2000 * L Baker et al AACR 2002 **Can Res 50:6344 1990

  3. INTERGROUP SARCOMA COMMITTEEHER2 and Cox-2 Expression in Synovial Sarcomas Her2/neu Cox-2

  4. EGF-R EXPRESSION ANDINHIBITION IN MPNST Intense membrane staining EGF-R inhibitors DeClue et al JCI 2000

  5. ICAS STUDIESMetastatic Disease ICAS #SarcomaTargetInhibitorPrior Rx S0330 MPNST EGF-R erlotinib N S0345 DFSP PDGF-R imatinib Y S0346 Synovial HER2* trastuzumab Y S0505 STS VEGF sorafenib Y

  6. ICAS STUDIESMetastatic Disease ICAS #SarcomaTargetInhibitorPrior Rx S0423 Chondro MTAP pemetrexed Y S0502 GIST VEGF bevacizumab N S0416 (COG) GIST(<30) kit imatinib N S0406 (RTOG) STS COX-2 celocoxib Y EWS0031(COG) Ewing’s dose density chemo N

  7. ICAS STUDIESPrimary Disease ICAS #SarcomaTargetInhibitorPrior Rx S0344 Chondro local surgery telomerase S0405 (COG) Synovial bcl-2 anti-sense N S0404 (ACSOG) STS array/microscopy N ACOSOG STS retroperitoneal XRT N

  8. ICASNEW ERA 2000 MOLECULAR REDEFINITION IMPROVE PRIMARY MANAGEMENT IDENTIFY TARGETED THERAPIES

More Related