1 / 49

The Diagnosis of SUBARACHNOID HEMORRHAGE

The Diagnosis of SUBARACHNOID HEMORRHAGE. Rob Hall PGY2 Emergency Medicine January 10th, 2002. Subarachnoid HEMORRHAGE. OBJECTIVES What does the Literature Say?. What is the sensitivity of CT? When should the LP be done? What is a positive LP? Should we be using spectophotometry?

mariko
Download Presentation

The Diagnosis of SUBARACHNOID HEMORRHAGE

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. The Diagnosis of SUBARACHNOIDHEMORRHAGE Rob Hall PGY2 Emergency Medicine January 10th, 2002

  2. SubarachnoidHEMORRHAGE

  3. OBJECTIVESWhat does the Literature Say? • What is the sensitivity of CT? • When should the LP be done? • What is a positive LP? • Should we be using spectophotometry? • Does a -ve CT and -ve LP rule out SAH? • Is lumbar puncture without CT safe?

  4. WHY? Misdiagnosis Mortality Angiography Literature The Diagnosis of SUBARACHNOIDHEMORRHAGE

  5. SENSIVITITY OF CT

  6. Reading Literature on CT and SAH • Generation • Technique • Radiologist • Time • Prospective • Spectrum Bias

  7. POSITIVE CT NEUROSURG WARD POSITIVE CT EMERG PT (R/O SAH) SPECTRUM BIAS

  8. TIMING OF CT:Kassel 1990Cooperative Aneurysm Study

  9. Sidman 1996 Retrospective Sensitivity 100% < 12hrs Sames 1996 Retrospective Sensitivity 93% < 24hrs SPECTRUM BIAS IGNORE RESULTS Sensitivity of CT

  10. van der Wee 1995Journal of Neurology, Neurosurgery, and Psychiatry • Prospective, N=175 • All <12hrs with SUDDEN ONSET H/A • 3rd generation CT done < 12hrs • Neuroradiologist + 2 general radiologists • Diagnosis of SAH in -ve CT • LP > 12 hrs • Xanthochromia by spectophotometry

  11. Van der Wee 1995 • CT +ve in 117/175 ---->LP +ve in 2/58 • Sensitivity < 12 hrs 98% (94.0 - 99.8) • Comments • probably the best study available • good diagnosis of SAH in CT -ve group • rate of SAH 68% (?spectrum bias) • note CI as low as 94% • note who read the films

  12. Morgenstern 1998Annals of Emergency Medicine • Prospective, N = 107 • Spectrum: “worst headache ever” • Only 107 enrolled of eligible 170 • 3rd generation CT • 2 Neuroradiologists • Diagnosis of SAH in -ve CT questionable

  13. Morgenstern 1998:Annals of Emergency Medicine • Diagnosis of SAH in CT -ve patients: • rbcs > 1000 in 1st tube and no decrease of 25% w.r.t. 3rd tube PLUS one of …… • visual xanthochromia • spec xanthocrhomia • positive d-dimer

  14. Morgenstern 1998:Annals of Emergency Medicine • Negative Predictive Value Overall • 97.5% (CI 91.2 - 99.7%) • Sensitivity < 24hrs • 93% (no confidence interval)

  15. Only 107/170 enrolled 10% refused LP 25% of LPs < 12hrs Questionable definition of +ve LP 20 patients with +ve spec defined as NO SAH, but no problems at 2yr follow up What if they missed even ONE patient < 24hrs 14/15 = 93.3% 13/15 = 86.7% Morgenstern 1998:Annals of Emergency Medicine

  16. TRUE sensitivity UNKNOWN EARLIER is BETTER PGY2 versus NEURORAD BEST estimate of sensitivity 0-24hrs 95% 24-48hrs 85% 48-72% 75% TO RULE OUT SAH, A LUMBAR PUNCTURE IS REQUIRED AFTER A NEGATIVE CT HEAD SUMMARY ON CT AND SAH

  17. LUMBAR PUNCTUREPathophysiology • RBCs passively lysed and oxidized to OXYHEMOGLOBIN • detectible as early as 2 hrs (Barrows 1955) • Oxyhemoblobin is actively converted to BILIRUBIN by hemoxidase enzyme found in choriod plexus and leptomeninges • bilirubin present by 6hrs (Barrows 1955) • max hemoxidase activity by 12hrs (Roost 1972)

  18. What is Xanthochromia? • The change in coloration of CSF • Due to oxyhemoblobin, bilirubin, or methemoglobin • BUT ----------> detected by VISION or SPECTOPHOTOMETRY?

  19. What can cause a false +ve LP for Xanthochromia? • Jaundice • Rifampin • Previous traumatic LP • Traumatic tap -----> CSF sits in lab > few hours

  20. TIMING OF LUMBAR PUNCTURE • Barrows 1955: oxyHb in 2hrs, bili in 6hrs • Roost 1972: hemoxidase max at 12hrs • Where does the 12hr delay come from? • Vermeulen 1989 • Walton 1956

  21. TIMING OF LP:Vermeulen 1989Journal of Neurology, Neurosurgery, and Psychiatry • Retrospective review of 111 patients with SAH diagnosed by blood on CT • ALL lumbar punctures done > 12hrs • Xanthochromia detected by spectophotometry • DOES NOT LOOK AT CT -ve PATIENTS • DOES NOT LOOK AT LP < 12hrs

  22. TIMING OF LP:Vermeulen 1989Journal of Neurology, Neurosurgery, and Psychiatry • TIMING SENSITIVITY • 12hrs - 2weeks 100% • 2 - 3 weeks 91% • 3 - 4 weeks 71%

  23. TIMING OF LP:Walton 1956Subarachnoid Hemorrhage. E & S Livingstone LTD. • Retrospective look at 256 cases of SAH • How was SAH diagnosed? • Xanthochromia detected visually. • Some results missing

  24. TIMING OF XANTHOCHROMIA:Walton 1956

  25. What is a positive LP? • RED BLOOD CELL COUNT? • LEAK versus MAJOR HEMORRHAGE • NO literature (Tourtelloote 1964 - none < 1000/mm3) • How can you tell from traumatic tap?

  26. SAH versus Traumatic LP • Opinion, crenated rbcs, erythrophages, d-dimer unreliable • Repeat LP only helpful if clear • FOUR tube method UNRELIABLE and does not detect SAH + traumatic tap • Vandermeulen 1996 • Buruma 1981

  27. SAH versus Traumatic LP • XANTHOCHROMIA is the only way to reliably distinguish between SAH and traumatic LP

  28. Visual detection? ? Poor sensitivity Spectophoto-metry? ? Poor specificity So how should we detect Xanthochromia?

  29. LITERATURE REVIEW:Visual versus spectophotometric detection of Xanthochromia

  30. Visual detection of Xanthochromiais INSENSITIVE:Soderstrom 1977: • N=32 • 12 ICH, 12 SDH, 8 SAH • Dx by CT + OR, angiogram, or autopsy • Vision detected 16 of 32 cases of xanthochromia on spectophotometry • Sensitivity 50% • ?when spec done

  31. Visual detection of Xanthochromiais INSENSITIVE:MacDonald 1988 • Retrospective review of 61 patients with angiographically proven aneurysms who had LP done • 28/61 had xanthochromia by vision for sensitivity of 46% • 13 LPs were done < 24hrs (any < 12hrs?) • exlcude LP < 24hrs….28/48 ------> 67%

  32. Spectophotometry is NONSPECIFIC: Morgenstern 1998 • 18 patients with +ve spectophotometry who didn’t meet their criteria for +ve LP • Followed for 2 years with no problems

  33. Spectophotometry is NONSPECIFIC: Foot 2001 • Retrospective study looking at the use/results of CT and LP in ED r/o SAH • +ve Xanthochromia = > 0.02 absorbance units at 415nm • 21 CT-ve, Xanthochromia +ve • 19 angiograms normal • 2 aneurysms

  34. Xanthochromia • Cruikshank 2001 • “A prospective study of LP on CT -ve patients undergoing r/o SAH to compare visual and spectophotometric detection of xanthochromia has never been done”.

  35. UNPUBLISHED DATA:J. Croft, G. Sutherland, A. Gibb • ALL CSF samples from calgary ED over a 14 months period • R/O SAH in 110 • Recorded • rbcs count • visual xanthochromia • spectophotometry absorption peak • spectophotometry optical density criteria

  36. LOCAL DATA

  37. SAH No SAH OD+ve 5 45 OD-ve 0 60 Sensitivity 5/5 = 100% Specificity 60/105 = 57% NPV 60/60 = 100% PPV 5/50 = 10% Optical Density Criteria

  38. SAH NO SAH Visual 5 4 xantho No visual 0 101 xantho Sensitivity 5/5 = 100% Specificity 101/105 = 96% NPV 101/101= 100% PPV 5/9 = 56% Visual Detection

  39. CONCLUSIONS Visual Xanthochromia did NOT miss any SAH Spectophotometry was not specific for SAH COMMENTS NO gold standard for SAH diagnosis NO long term f/u to prove that SAH wasn’t missed Small numbers One missed SAH ---> 5/5 to 5/6 ---> 83% LOCAL DATA

  40. Summary on Lumbar Puncture • LP isn’t perfect either • LP should be done > 10 - 12 hrs (spectrum) • Xanthochromia is only way to reliably distinguish SAH from traumatic tap • Literature is unclear whether visual or spectophotometric detection of xanthochromia is superior

  41. Evidence this does NOT occur…. van Ginn1988: 71 patients followed to 3 years, no problems Markus 1991: 16 patients followed to 20 months, no problems Harling 1994: 14 pts followed 18-30 mo, no problems Evidence that this DOES occur….. Nine case reports in literature Some had LP < 12hrs Some used visual, some used spec Does a negative CT and LP rule out SAH?

  42. PERSPECTIVE ON POSSIBLE MISSED DIAGNOSIS RATE

  43. Does a -ve CT and LP rule out SAH? • If LP done > 12hrs ---------> YES • Risk of angiogram > chance of SAH with -ve CT and LP

  44. DIAGNOSTIC ALGORITHM

  45. LP without CT • Why wouldn’t you want to do this? • Risk of herniation • CT provides much additional information • How do you know this is a SAH? • How do you know there aren’t complications of the SAH that increase the risk of herniation

  46. LP without CT • Herniation • Mass effect from hematoma or hydrocephalus with a SAH, or a different dx (ICH, tumor, etc) • Normal LOC and NO focal signs • Hillman 1986: 2.2% acute deterioration after LP; 10% had hematomas associated with SAH • Duffy 1982: 12% with proven SAH (spectrum bias) deteriorated while needle in back

  47. LP without CT • Additional information on CT • dx of non-aneurysmal causes: AVM, tumor, ICH, hypertensive hem, perimesencephalic • look for acute complications: hydrocepahlus, ICH, intraventricular blood requiring a drain • amount of bleeding is prognostic • bleeding on CT can help localize aneurysm and identify multiple aneurysms

  48. LP without CT • How do you know that the acute H/A isn’t due to an intraparenchymal hemorrhage? • Van Gijn 1980: retrospective review of all patients with initial dx as SAH • 15% had intraparenchymal hemorrhage • 8% were in posterior fossa

  49. LP without CT • Summary • There is NO literature supporting LP without CT (Schull 1999: model only) • There is SOME literature documenting the risks • Risks and lack of additional information are not justified in a tertiary care center • May be reasonable in periphery if no access to CT although transfer in for CT is preferable

More Related