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Suppl. Figure 2. A. siControl. siNOV3. siNOV4. siNOV5. siNOV6. CFSC. 15 min PDGF-B (20 ng/ml). -. -. -. -. -. -. +. +. +. +. +. +. kD. pTyr. 190. PDGFR . 190. PDGFR . 190. pAKT. 60. total AKT. 60. 44 42. pERK1/2. 44 42. total ERK1/2. pp38. 39. p38. 39.
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Suppl. Figure 2 A siControl siNOV3 siNOV4 siNOV5 siNOV6 CFSC 15 min PDGF-B (20 ng/ml) - - - - - - + + + + + + kD pTyr 190 PDGFR 190 PDGFR 190 pAKT 60 total AKT 60 44 42 pERK1/2 44 42 total ERK1/2 pp38 39 p38 39 B CFSC medium CCN3/NOV (48 hrs) 200 control 150 with PDGF concentration (pg/ml) 100 50 0 siNOV3 siNOV4 siNOV5 siNOV6 siControl 0.5% FCS