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Viruses. Homework. Cell Analogy Project due Monday 10/5. Objectives. Know the two major differences between a virus and a cell Know how a virus replicates itself. Viruses. How many viruses can the class name off the tops of our heads?. Viruses.
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Homework • Cell Analogy Project due Monday 10/5
Objectives • Know the two major differences between a virus and a cell • Know how a virus replicates itself
Viruses • How many viruses can the class name off the tops of our heads?
Viruses • How many viruses can the class name off the tops of our heads? • HIV, influenza, H1N1, rhinovirus, herpes, HPV, smallpox, polio, chickenpox, ebola, hanta, avian influenza, SARS, hepatitis, norovirus, dengue, Epstein-Barr, marburg, filoviruses • Major viruses you probably haven’t heard of include viruses infecting other animals (SIV, foot and mouth), many plant viruses (tobacco mosaic virus), bacteria viruses like T4 phage
Viruses • Is a virus another kind of bacteria? • How do they cause damage to the infected organism?
Definition • Virus = a microscopic infectious agent that replicates but is not truly alive* *By most scientists’ reckoning
Viruses • Viruses are not cells. • They have only two real parts, and only one of them can also be found in cells.
Viruses • They consist of a protein capsid (envelope or shell) that contains genetic material. • Often this genetic material is DNA, like a cell. Sometimes it’s closely-related RNA instead, in what are called retroviruses.
Viruses • This means cells have what parts that viruses don’t? • What does this mean that viruses cannot do for themselves?
Viruses • A virus can do one thing and one thing only: they force a cell (a host) to make more copies of the virus.
Viral Replication • http://videos.howstuffworks.com/hsw/8061-viruses-how-viruses-work-video.htm • http://www.hhmi.org/biointeractive/media/viral_lifecycle-lg.mov • http://student.ccbcmd.edu/courses/bio141/lecguide/unit3/viruses/adlyt.html • In spite of this, it’s not usually lysing cells that cause pain and symptoms, but it’s actually the body’s defense mechanisms that cause discomfort.
Checkpoint • How is a virus different from a cell? • How is viral replication different from how a cell can reproduce?
Viruses in History • Smallpox and the destruction of Native American civilizations • Mexico’s population: 18 million to 1.6 million in 100 years • American & Canadian Nations reduced to 5% of former population (20 million) in 200 years • Smallpox eradication in 20th century
Viruses in History • Influenza Pandemic of 1918 • http://videos.howstuffworks.com/hsw/8063-viruses-the-influenza-pandemic-of-1918-video.htm
Viruses in History • HIV pandemic • HIV mutated from SIV • The more closely related two species are, the easier it is for them to share viral illnesses • Discovered in the 1980s, 25 million dead since 1981 • 1/3 in Subsaharan Africa, ~6% children • Fast mutating, no cure or vaccine yet. • Clearly understood transmission & pathology • Many treatments & application of evolutionary principles mean it’s no longer “a death sentence” with medical assistance, but still a pandemic.
Viruses in History • Applications in Biotechnology • Knowing what you do about how a virus replicates, why do you think scientists look to viruses to help treat genetic disorders?
Unanswered Questions • Last remaining stores of smallpox in U.S. and Russia? • Herd immunity vs. individual freedoms - parents refuse vaccination for children? • Viruses used to modify genes for agriculture, medicine?