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Prions diseases

Prions diseases. Scrapie ovine oldest prion disease (XVIIIth century)) Mad Cow disease the most famous prion disease Creutzfeldt-Jacob disease the corresponding in human (1920). The agent - prion protein PrPc (cellular) : synthesised by normal cell, unknown fonction,

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Prions diseases

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  1. Prions diseases

  2. Scrapie ovine oldest prion disease (XVIIIth century)) Mad Cow disease the most famous prion disease Creutzfeldt-Jacob disease the corresponding in human (1920)

  3. The agent - prion protein PrPc (cellular) : synthesised by normal cell, unknown fonction, PrPsc (scrapie) : same aa (amino acids) sequence as PrPc abnormal conformation (3D structure) - contamination : il faut que je lise la doc (alimentation? Sang?) - propagation : still unknown existing hypothesis : PrPsc changes PrPc conformation (Stimulus? How?) in PrPsc structure (exponential progapation) The neuronal degenerative (à vérifier) mechanism new 3D structure is resistant to enzyme digest PrPsc accumulation no more neurone-neurone communication Consequences (à fignoler) in animals : tremblements, chuttes, etc… (je ne m’en rappelle plus (un des papier les décrits bien dans l’intro mais je vais voir avec ce que j’ai)

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