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BROADER IMPACTS

Blood Coagulation Inducing Synthetic Polymer Hydrogel Peter Kofinas, University of Maryland College Park, DMR 1041535.

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BROADER IMPACTS

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  1. Blood Coagulation Inducing Synthetic Polymer HydrogelPeter Kofinas, University of Maryland College Park, DMR 1041535 This work aims to investigate the use of synthetic polymer hydrogels as hemostatic agents in surgical and traumatic bleeding. The hydrogels ability to activate coagulation factor VII (FVII) has been characterized in vitro. The hydrogel characteristics that are necessary to accelerative or augment coagulation in vivo have also been identified. This work is important because of the current cost and safety issues of commercial hemostatic products. Figure: The in vitro clot formed as a result of FVII activation, characterized by (A) H&E staining (B) IHC staining and (C) ESEM surface imaging. (D) is a micrograph depicting the cross section of a liver incision to which the hydrogel was applied, using Carstairs’ method staining. A B C D

  2. Blood Coagulation Inducing Synthetic Polymer HydrogelPeter Kofinas, University of Maryland College Park, DMR 1041535 BROADER IMPACTS This work has had a great deal of education outreach associated with it in the last year, including the mentoring and participation of high school and international students. If successful, the societal and technological outputs would lead to increased hemostatic availability in low resource settings as well as use in populations affected by bleeding disorders. Figure: Images A-C depict a liver laceration: the incision, the hydrogel application, and the stop of blood flow. Image D is a H&E stained micrograph of the cross-section of a liver incision site that had hydrogel applied for 5 minutes. A B C D

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