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Mathematical modelling in biomedical fluid dynamics

Mathematical modelling in biomedical fluid dynamics. Dr David Smith. 1. PhD, applied mathematics, Birmingham (2001-2005) Prof John Blake, Dr Eamonn Gaffney Mucus transport fluid mechanics MRC training fellowship (2006-2009), Medicine / Maths

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Mathematical modelling in biomedical fluid dynamics

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  1. Mathematical modelling in biomedical fluid dynamics Dr David Smith 1

  2. PhD, applied mathematics, Birmingham (2001-2005) Prof John Blake, Dr Eamonn Gaffney Mucus transport fluid mechanics MRC training fellowship (2006-2009), Medicine / Maths Sperm motility imaging and modelling, with Dr Jackson Kirkman-Brown, Birmingham Women’s Hospital Science City IT Theme Research fellow (December 2009 – November 2012): ‘High performance computing and novel imaging for fluid mechanics in reproduction’, Mathematics, Birmingham Joint-appointment with Warwick Engineering and Centre for Scientific Computing: Prof Bryanston-Cross, Dr Timmerman, Daniel Claus, Dr Denissenko Interactions with TM (sperm imaging and modelling, also cancer metabolomics) Interactions with AM (drug delivery, characterisation of biofluids and cells)

  3. Centre for Human Reproductive Science An international network, based at Birmingham Women’s Hospital and the University Research lead: Dr Jackson Kirkman-Brown (TM Reproduction) Based in an IVF clinic, ChRS provides unique access to: human material (sperm, eggs, reproductive tract) clinical experience – what really works ethical permissions to work with human material new infrastructure through Science City 3

  4. Subfertility affects 1 in 6 couples in the UK; male factors are present in around half of all cases • Motility, the ability of sperm to swim, is the most common problem • Treatments for male subfertility such as IVF/ICSI are invasive for the for the female and resulting embryo and carry risk • Unplanned pregnancy • Half of all pregnancies are unplanned • In the developing world, this carries a significant health risk (1 death in the world per minute from pregnancy-related causes) • Motility is a potential contraceptive target 4

  5. Fluid mechanics underlying new medicine Fertell: this test is effective because it utilises the correct fluid viscosity New developments will require more sophisticated understanding. Examples include: screening of drug treatments and selecting high quality sperm for IVF optimising intra-uterine insemination and embryo transfer delivery vehicles for new drugs 5

  6. Integrated research • Imaging: high-speed 2D and 3D imaging of how the flagellum propels the cell, in normal progressive state, and when stimulated by hormones and aromatics • Fluid properties: physiological viscosity and viscoelasticity have radical effects on flagellar movement, progression and behaviour • Mechanics: through fluid mechanical models we can interpret • energy consumption & energy pathways • how intracellular signals cause changes in behaviour through flagellum movement • this requires computational modelling

  7. Imaging and fluid properties Arclength s k Time

  8. Fluid dynamic power dissipation max. 4 x 10-8 W/m s t

  9. Funding MRC and Wellcome trust fellowships EPSRC studentships Brazilian govt. funding & Hester Cordelia Parsons Fund – Hermes Gadêlha Nuffield Undergraduate Bursaries – Tom Johnson KAUST funding to Dr Eamonn Gaffney STFC MRC Biomarker Strategic Call Science City: Reproduction Infrastructure Thanks to Birmingham Women’s for supporting our research 11

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