1 / 9

Gene Regulation

Gene Regulation. Levels of Regulation. DNA rearrangement Immune System rearranges DNA Bacteria can change DNA in chromosomes Not as common as other methods. Transcriptional Regulation. Regulate RNA polymerase starting transcription Splicing choices can regulate gene expression

masao
Download Presentation

Gene Regulation

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Gene Regulation

  2. Levels of Regulation • DNA rearrangement • Immune System rearranges DNA • Bacteria can change DNA in chromosomes • Not as common as other methods

  3. Transcriptional Regulation • Regulate RNA polymerase starting transcription • Splicing choices can regulate gene expression • MRNA stability – How fast MRNA degrades, can protect it with regulator

  4. Translational Regulation • Wrap up RNA so it cant get to Ribosome • Microrna – 21 base pair sequences interfere with translation of MRNA

  5. Post-Translational Regulation • Activate with enzyme • Mitochondria

  6. Most Important • Transcriptional Regulation is most important • 80% of red blood cells is alpha or betaglobin • Describe Lac Operon in E Coli

  7. E Coli • Bacteria would like glucose to grow on • Glucose ->ATP->Energy • Lactose if it cant find glucose • Uses beta-galactosidase to break down Lactose into glucose • In the presence of Lactose, 10% of proteins will be Beta-gal • Cant keep that level in absence of beta-gal or selection would favor more efficient system • lactose permease allows Lactose to enter cell

  8. Lac Operon Promoter LacZ LacY LacA PLac B-gal Permease Promoter LacI PI Lac Repressor

  9. Cell Function

More Related