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Bioengineering with (only) DNA

Bioengineering with (only) DNA. Dave Zhang 2nd Annual Unither Nanomedical and Telemedical Technology Conference 26 Feb 2009. DNA vs. genetic engineering. Genetic engineering. DNA engineering. A. Z. Ansari, Nature Chemical Biology , 2007. Nanoengineer, by Nanorex

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Bioengineering with (only) DNA

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  1. Bioengineering with (only) DNA • Dave Zhang • 2nd Annual Unither Nanomedical and Telemedical Technology Conference • 26 Feb 2009

  2. DNA vs. genetic engineering Genetic engineering DNA engineering A. Z. Ansari, Nature Chemical Biology, 2007 Nanoengineer, by Nanorex http://nanoengineer-1.com/content/index.php?option=com_content&task=view&id=37&Itemid=47

  3. DNA abstraction Michael Ströck, http://en.wikipedia.org/wiki/File:DNA_Overview.png

  4. Structures Cell wall Cilia Actin and myosin Lacey Samuels, https://www.biomedia.cellbiology.ubc.ca/cellbiol/user/scripts/qry_media_id.php?media_id=212 http://online-media.uni-marburg.de/histologie/introhis/HIS/txt/muscsem/musc01_sem.htm C. Daghlian, http://refm.dartmouth.edu/images/mammalianLungSEM/source/9.html

  5. Structures 2 um x 8 um 500,000 tiles! Two-dimensional lattice Aperiodic structures Three-dimensional shapes E. Winfree, F. Liu, L.A. Wenzler, N.C. Seeman, Nature 1998 Y. He, T. Ye, M. Su, C. Zhang, A.E. Ribbe, W. Jiang, C. Mao, Nature 2008 P. Rothemund, Nature 2006

  6. Logic and actuators Yum! Granite Amoeba Algae Micrographia, http://www.micrographia.com/specbiol/protis/homamoeb/amoe0100/amoeba21.htm

  7. Logical processing Boolean Logic

  8. Logical processing Output Input 1 Input 2 Logical AND gate substrate D. Y. Zhang, in preparation

  9. Logical processing D. Y. Zhang, in preparation

  10. Logical processing NAND gate is universal! D. Y. Zhang, in preparation

  11. Actuators and motors B. Yurke, A.J. Turberfield, A.P. Mills, F. C. Simmel, J.L. Neumann, Nature 2000

  12. Amplification and reproduction Jeff Hardin, http://worms.zoology.wisc.edu/dd2/echino/cleavage/intro.html http://www.bunny-rabbits.com/ http://www.kindplanet.org/thesanctuary.html

  13. Amplification and reproduction

  14. Amplification and reproduction Cons: Spontaneous generation Not really alive: more like crystallization in a supersaturated solution Pro: If we know what we’re looking for, we can amplify its concentration dynamically. D. Y. Zhang, A.J. Turberfield, B. Yurke, E. Winfree, Science 2007

  15. Amplification and reproduction

  16. Interaction with general chemistry Small organic group Boom! Z. J. Gartner, B. N. Tse, R. Grubina, J.B. Doyon, T.M. Snyder, D.R. Liu, Science 2004 Adapted from David Liu’s website: http://evolve.harvard.edu/rschdts.htm#DTS

  17. DNA engineering as a nanomedical tool • Instrument-free disease detection • Embedded control of apoptosis • Control of developmental biology

  18. Parting Thought http://www.kurzweilai.net/articles/images/Carlson(PaceAndProliferation)figure1.gif

  19. Thanks for listening! (and thanks to the following for their money:)

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