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Institute of Biomedical & Genetic Engineering (IBGE)

Institute of Biomedical & Genetic Engineering (IBGE). Nafees Ahmad, PhD (Germany) Principle Scientific Officer (PSO) Group Head: Functional Genomics. 24-Mauve area, G-9/1, Islamabad. Scope of IBGE. Services. Biomedical Research. Molecular Diagnostics. Cancer. HBV HCV HLA Forensic

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Institute of Biomedical & Genetic Engineering (IBGE)

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  1. Institute of Biomedical & Genetic Engineering (IBGE) Nafees Ahmad, PhD(Germany) Principle Scientific Officer (PSO) Group Head: Functional Genomics 24-Mauve area, G-9/1, Islamabad

  2. Scope of IBGE Services Biomedical Research Molecular Diagnostics Cancer HBV HCV HLA Forensic Thalassemia Neurodegenerative Carrier Screening Neuropsychiatric Skin (XP, Ichthyosis) BCR-ABL FLT3 JAK2 EGFR Genetic Counseling Inherited Disorders For details visit: www.Iibge.edu.pk

  3. Scope of Functional genomics

  4. Research Projects Project 1: Genetic and Molecular basis of Neurodegenerative movement disorders (IBGE-RGGD-FG-QP-01) Project 2: Genetic and Molecular basis of Neuropsychiatric disorders (IBGE-RGGD-FG-QP-02) Project 3: Targeted Cancer therapeutics(IBGE-RGGD-FG-QP-03) Project 4: Cancer Diagnostic and Prognostic Biomarkers (IBGE-RGGD-FG-QP-04)

  5. Familial Adenomatous Polyposis (FAP) An autosomal dominant inherited condition ? ?

  6. Genetics of (FAP) • Mutation in • APC gene – a key tumor suppressor gene (80-90%) • MUTYH gene – a DNA repair gene (10-20%) Chromosome 5 Chromosome 1 MUTYH (1p34.1) APC (5q22.2)

  7. Mutation Cluster region of APC gene Exon 15

  8. Colorectal Cancer Nature Reviews Cancer 3, 615-622 (August 2003)

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