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Gene-Environment Interactions

Gene-Environment Interactions. Introduction Genotype Phenotype Genes, the organism, and the environment What is a gene-environment interaction? Waddington’s cannalization principle Gottesman’s Range Of Reaction principle Genetic constraints on individuals

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Gene-Environment Interactions

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  1. Gene-Environment Interactions • Introduction • Genotype • Phenotype • Genes, the organism, and the environment • What is a gene-environment interaction? • Waddington’s cannalization principle • Gottesman’s Range Of Reaction principle • Genetic constraints on individuals • Problems with range of reaction • Kinship studies • Feedback in gene-environment interactions • Scarr and McCartney model • Three different gene-environment interactions • Passive gene influences • Evocative gene influences • Active gene influences • The ahistorical-historical dimension • Questions about gene-environment interactions • Is there a developmental program? • Do genes determine the phenotype? • Do genes determine capacity? • Do genes determine tendencies?

  2. What do we mean by gene – environment interactions? • Variations in any level of the environment can have an impact on the development of the organism • Experiments on the Himalayan rabbit • Studies of fur color • How do we study gene-environment interactions? • Keep environments of different genotypes constant • Keep genotype constant while varying the environment

  3. Waddington’s canalization principle • Although both influence development, genes might influence some attributes more than others • Conrad Waddington • Canalization - Cases in which genes restrict development to a small number of outcomes • Example – Babbling in infants • Canalization and critical periods • Implications of canalization • Multiple pathways of development • Some circumstances, genes may limit the extent to which environments can influence development

  4. Gottesman’s Range of Reaction Principle • Individual genotypes might operate in ways to restrict development or constrain outcome • Range of reaction principle: • Genotype, or genetic structure, sets the limits on the range of possible phenotypes that a person might display in response to different environments: • Example: Intellectual development in children

  5. The Range of Reaction Principle Reaction Ranges A A B B C C

  6. Gottesman’s Range of Reaction Principle • Individual genotypes might operate in ways to restrict development or constrain outcome • Range of reaction principle: • Genotype, or genetic structure, sets the limits on the range of possible phenotypes that a person might display in response to different environments: • Example: Intellectual development in children • Generally, a statement about the interplay between environment and heredity • Problems with range of reaction principle • Issues in terms of how to investigate principle • Issues in terms of finding genetically identical individuals. • Kinship studies: • Studies in which members of same biological family compared to see how similar in attribute(s) • Monozygotic twins – genetically identical • Dizygotic twins, siblings – genetically similar • Half siblings

  7. Child’s Phenotype The Scarr and McCartney Model Child’s Genes Child’s Environment

  8. Child’s Genes Child’s Phenotype Child’s Environment The Scarr and McCartney Model, con’t Parent’s Genes

  9. Child’s Genes Parent’s Genes Child’s Phenotype Child’s Environment The Scarr and McCartney Model, con’t

  10. Child’s Genes Parent’s Genes Child’s Phenotype Child’s Environment The Scarr and McCartney Model, con’t

  11. Three Different Genotype-Environment Interactions • Passive gene influences • Parents contribute to development in two ways: • Provide genetic material • Structure environment socially and emotionally • Because environments provided/created by parents depend on their genotype, environments will be generally matched to children’s genotype • Evocative gene influences • Child’s heritable characteristics affect behavior of others towards child • Active gene influences (niche picking) • Environments children prefer and seek out those that are most compatible with genetic predispositions

  12. Questions aboutGenotype-Environment Interactions • Is there a developmental program? • Analogy between genetic code and computer program • Do genes determine the phenotype? • Once genotype is fixed, phenotype is determined • Do genes determine capacities? • Genotype sets the absolute limits on the nature of the phenotype • Do genes determine tendencies? • Genotype determines a general tendency toward a particular phenotype • Example – the genetic contribution towards excitability is a tendency to get excitedv

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