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7. 7. 6. 6. 5. 5. 4. 4. 3. 3. 2. 2. 1. 1. Hypermethylators. Low-Frequency Methylators. A. MDA-MB-435S. MDA-MB-436. MDA-MB-231. MDA-MB-468. MDA-MB-453. MDA-MB-415. MCF12A. ZR-75-1. HS578T. SKBR3. BT549. MCF7. BT20. DNMT Activity. (Relative Activity Units). 3. B. 2.
E N D
7 7 6 6 5 5 4 4 3 3 2 2 1 1 Hypermethylators Low-Frequency Methylators A MDA-MB-435S MDA-MB-436 MDA-MB-231 MDA-MB-468 MDA-MB-453 MDA-MB-415 MCF12A ZR-75-1 HS578T SKBR3 BT549 MCF7 BT20 DNMT Activity (Relative Activity Units) 3 B 2 DNMT1 Protein (Relative Protein Units) 1 3 C 2 DNMT3a Protein (Relative Protein Units) 1 D DNMT3b Protein (Relative Protein Units)