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NCMHD Southeastern Exploratory Sickle Cell Center of Excellence. Principal Investigators: Abdullah Kutlar, MD Robert Gibson, PhD. Participating Institutions: Medical College of GA Morehouse SOM University of Florida. Components of the Center. Administrative Core Research Core
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NCMHD Southeastern Exploratory Sickle Cell Center of Excellence Principal Investigators: Abdullah Kutlar, MD Robert Gibson, PhD
Participating Institutions:Medical College of GAMorehouse SOMUniversity of Florida
Components of the Center • Administrative Core • Research Core • Training and Education Core • Community Engagement/Outreach Core
Administrative Core • Oversee and provide administrative assistance for the Center • Serve as a central communication point • Coordinate research activities • Financial responsibility for grant administration
Annual Health Disparity Conference • Increase community involvement and participation of patients and their families • Educate health care providers and members of the community regarding health disparities • Create opportunities for communication and synergy across various health disparity research activities at MCG as well as the University of Florida and Morehouse School of Medicine
Research Core • Dr. Dorothy Tuan, PI
Research Project 1Abdullah Kutlar, PI • Mu Opioid Polymorphisms as Genetic Modifiers of Pain and Opioid Use in SCD • Determine variations of the Mu Opioid gene on pain and perception of pain in patients with sickle cell disease (Dr. Xiaoling Wang; Dr. Ferdane Kutlar) • Using a pain algometer, test the patient’s pain threshhold (Dr. Roger Fillingim, UFL) • Patients to complete pain diaries; determine frequency and dose of pain medications and correlate with Mu Opioid gene (Dr. Steffen Meiler)
Research Project 2Dr. Dorothy Tuan, PI • An NF-Y mediated GATA switch mechanism in g-globin gene reactivation by HU • To determine the mechanism by which hydroxyurea (the only drug currently approved by the FDA for use in sickle cell disease) helps to alleviate complications of the disease • This knowledge will ultimately allow new drugs to be developed giving patients a choice in treatment options
Research Project 3Dr. Tohru Ikuta, PI • Mechanisms of HU for SCD • To determine intracellular signaling pathways that play a critical role in HU-induced Hb F expression • To determine whether HU-induced Hb F expression is further increased by combining a cAMP-dependent PDE inhibitor
Research Training/Education CoreDr. Thomas Adamkiewicz, PI (Morehouse School of Medicine)
Research Training/Education CoreDr. Thomas Adamkiewicz, PI (Morehouse) • Develop ongoing education programs for the present and future family medicine physicians as well as other providers of care for patients with SCD (Dr. Paul Forney; Dr. Joseph Hobbs) • Use of information technology to identify those that would most benefit from education
Community Engagement/Outreach CoreDr. Robert Gibson, PI • Promoting Health Care Transition/Health Literacy for Young People with SCD (Dr. Robert Gibson) • Outcomes of the Implementation of a Clinical Pathway for Uncomplicated Sickle Cell Vaso–Occlusive Crisis (Dr. Matthew Lyon) • The Creation and Evaluation of an Advanced Medical Home for adults with SCD (Dr. Richard Lottenberg, UFL)
Anticipated Benefits/Outcomes • Improvement in care for adult sickle cell patients • Evidence based care (protocols) • Medical Home (involvement of PCPs) • Improved outcomes/patient satisfaction in ED encounters • Transition from pediatric to adult care • Availability of SCD clinical trials for SCD patients in the Albany area (infrastructure through Phoebe Sickle Cell Clinic)