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FORMATS OF NIH APPLICATIONS

Explore the various NIH career development mechanisms, such as K01, K08, K22, K23, and K25, to support research scientists and clinicians at different career stages. Learn about eligibility requirements, funding details, and success rates. Discover how these awards can advance your research career.

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FORMATS OF NIH APPLICATIONS

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  1. FORMATS OF NIH APPLICATIONS

  2. Acknowledgment James S. Panagis, MD, MPH Director, Orthopaedics Program NIAMS, NIH, DHHS 6701 Democracy Boulevard, #800Bethesda, MD 20892(P) 301-594-5055(F) 301-480-4543jp149d@nih.gov

  3. NIH • 27 Institutes and Centers • Budgets (FY 2005): • NIH = ~$28 Billion • NIAMS = ~$511 Million • > 70,000 applications in FY 2004

  4. Types of Applications • Unsolicited • Solicited • Program Announcement (PA) • Request for Applications (RFA) • Request for Contracts (RFC)

  5. NIH Receipt, Review & Award Cycles

  6. Funding Mechanisms • Training: F 31, 32, 33 • Career Development: K 01, 02, 08, 22, 23, 24, 25 • P 01 • P 30, 50, 60 • Research: R 01, 03, 15, 21, 37 • R 41, 42, 43, 44 • T 32 • U 01

  7. Medical School Residency Fellowship Junior Faculty Career T32 T32 F32 K01, K08, K22, K23, R03, R21 R01, R21, K24 Career Timeline & NIH Mechanisms

  8. What is the Right Mechanism? • Your training & experience • What you need • What you would like to do (time & amount)

  9. Career Development Award “K” Awards

  10. Mentored Research Scientist Development Award K01 http://grants.nih.gov/grants/guide/pa-files/PA-00-019.html

  11. K01 • Purpose is to develop outstanding scientists • 3 – 5 yrs of supervised research experience • 75 % effort • Ineligible if prior R01, R29, K(01,07,23), P(01,50) • Salary: Salary determined by I/C • NIAMS=$75,000)

  12. K01 • Research Dev. Support: i.e., tuition, fees & research support. Amount varies (NIAMS = $20,000) • Facilities & Admin costs: Fixed at 8% • Mentor should have independent research support (mentor is not salaried) • Standard receipt dates

  13. Mentored Clinician Scientist Development Award K08 http://grants.nih.gov/grants/guide/pa-files/PA-00-003.html

  14. K08 • Purpose is to develop clinical research scientists • Similar format/regulations to K01 • 52.3% success rate

  15. NIAMS Career Transition Award K22 http://www.niams.nih.gov/rtac/funding/grants/pa/par_02_056.pdf

  16. K22 • Provides training within a NIAMS intramural lab followed by support in an extramural institution • Ineligible if prior R01, R29, SBIR/STTR, P01, P50, K08 • Provides up to $150,000/YR for all years

  17. K22 • Intramural (Phase I): Salary based upon training &experience. • Extramural (Phase II): Salary up to $75,000. Can be supplemented. 75% effort. Up to $75,000 for research supplies. • F & A: 8% • Standard receipt dates • 40.2 % success rate

  18. Mentored Patient-Oriented Research Career Development Award K23 http://grants.nih.gov/grants/guide/pa-files/PA-00-004.html

  19. K23 • Purpose is to develop clinical researchers • 3 – 5 yrs of support; 75% effort • Same eligibility as the other K’s • Salary : Varies by I/C. May be supplemented (NIAMS = $75,000) • Res. Development Support: Up to $25,000 • F & A: 8%

  20. K23 • Mentors should have independent research support • Can not be salaried. • Standard receipt dates • 46.6 % success rate

  21. Mentored Quantitative Research Career Development Award K25 http://grants.nih.gov/grants/guide/pa-files/PA-02-127.html

  22. K25 • Purpose is to foster interdisciplinary collaboration in biomedical research by supporting career development experiences for scientists with quantitative and engineering backgrounds • 3-5 YRS of support • 75% effort • Similar format/regulations as other Ks

  23. NIAMS Small Grant Award for New Investigators R03 http://www.niams.nih.gov/rtac/funding/grants/pa/par_04_002.pdf

  24. R03 • Funding for pilot/preliminary data • Ineligible if previous/current large mechanism support, or NIAMS R21 • Receipt dates: 2/24/05, 6/24/05, 10/24/05 • Up to 3 YRS of support • Up to $50,000 direct costs/YR • Limited to 2 small grant awards/career • Lower success rate due to # of apps

  25. Exploratory/Developmental Research Grant R21

  26. R21 • Appropriate for early stages of research that are high risk because of possible failure, but if successful, may be of significant benefit • 2 YRS of support; $275,000 split over the 2 yrs

  27. R21 Program Announcements • PA-03-058: Exploratory/Developmental (R21) Bioengineering Research Grant (EBRG) http://www.niams.nih.gov/rtac/funding/grants/pa/pa_03_058.pdf • PA-03-107: NIH Exploratory/Developmental Research Grant Award (R21) http://www.niams.nih.gov/rtac/funding/grants/pa/pa_03_107.pdf

  28. Shorter Duration R01 • Prove feasibility, setting stage for what to follow in a competing continuation • Suggest 3 years • Avoids being “overly ambitious” in an R03, or if limited preliminary data, “high risk” for a longer duration R01

  29. NIH Loan Repayment Program for Clinical Researchers • Purpose: To recruit & retain clinical investigators • Re-pays up to $35,000/YR of educational loan expenses for each YR of obligated service • Also pays 39% of loan repayment to IRS • Must agree to engage in clinical research a minimum of 2 years http://www.lrp.nih.gov

  30. Tips • Contact NIH Program Officer (PO) • Read application instructions carefully • Focus on perfecting the abstract & specific aims • Communicate clearly & thoroughly • Allow time for a thorough editing & proofreading • Have knowledgeable colleagues review application • Send in supplemental progress materials, papers • Speak with NIH PO post-review • Be prepared to revise in response to critique

  31. BE PERSISTENT

  32. Resources • NIAMS Homepage: http://www.niams.nih.gov • NIH Grants Page: http://grants1.nih.gov/grants/oer.htm • “Welcome Wagon”: http://grants1.nih.gov/grants/funding/welcomewagon.htm • “Getting Started at the NIH”: http://grants1.nih.gov/grants/useful_links.htm • “Grant Writing Tips”: http://grants1.nih.gov/grants/grant_tips.htm

  33. Resources: Tutorials • How to Write a Grant Application: www.niaid.nih.gov/ncn/grants/write/write.pdf • Advice on Research Training & Career Awards: www.niaid.nih.gov/ncn/grants/advice/advice.pdf • How to Write an Application Involving Animals: www.niaid.nih.gov/ncn/clinical/researchanimals/tutorial/researchanimals.pdf • How to Write a Human Subjects Application: www.niaid.nih.gov/ncn/clinical/humansubjects/humansubjects.pdf • Annotated R01 Grant Application: www.niaid.nih.gov/ncn/grants/app/default.htm

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