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Thanks

Thanks. Training Course: Michael Shen, Barb Foster, Simon Hayward Pathology Workshop: Scott Shapell, Bob Cardiff Meeting: Cory Abate-Shen, Norm Greenberg, Bob Matusik, Judi Hayward. Submit your model to the MMHCC website!. Validating/credentialing the histology. get Cardiff on your team

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Thanks

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  1. Thanks • Training Course: Michael Shen, Barb Foster, Simon Hayward • Pathology Workshop: Scott Shapell, Bob Cardiff • Meeting: Cory Abate-Shen, Norm Greenberg, Bob Matusik, Judi Hayward

  2. Submit your model to the MMHCC website!

  3. Validating/credentialing the histology • get Cardiff on your team • get one of Cardiff’s “credentialed” pathologists on your team • examine your results in the context of MMHCC pathology committee guidelines • compare to images available on the website

  4. Issues for future prostate models • Strategies to examine hormone-independent disease progression (since current transgenic promoters are androgen regulated) • Building in biomarkers for monitoring disease progression (secreted proteins, luciferase or GFP for imaging) • Modeling metastasis to bone

  5. Issues for future prostate models (continued) • Targeting the appropriate cancer-initiating cell (stem cell, progenitor cell, secretory cell) • Initiating transgene expression during development versus regulated, inducible expression (toxicity issues, appropriate timing with aging events) • whole organ expression versus somatic activation in single cells • Why do so many models develop PIN without invasion?

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