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Filler Liquid Injectable Silicone

Filler. ? Filler ?- Filler materials are consists of highly viscous fluid or polymer particle suspension that include synthetic polymers and autologous tissue- The demand for safe, effective, long-lasting, biocompatible dermal filler materials is increasing.* Autologous

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Filler Liquid Injectable Silicone

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    1. Filler & Liquid Injectable Silicone Lee Hun Gu Kim Byung Gwan

    2. Filler ? Filler ? - Filler materials are consists of highly viscous fluid or polymer particle suspension that include synthetic polymers and autologous tissue - The demand for safe, effective, long-lasting, biocompatible dermal filler materials is increasing. * Autologous : from self-tissue.

    3. An Overview of Filler Fillers can be classified into three groups. - Permanent Filler include polymer gel (Silicon(synthetic) and Aquamid(synthetic)), nondegradable polymer microspheres suspended in resorbable liquid (Artefill) - Semipermanent filler include slowly degradable polymer microspheres suspended in resorbable liquid, and autologous fat. - Nonpermanent Filler include natural filler such as Collagen and hyaluronic acids (Lestylane).

    4. The ideal soft tissue filler substance Safe Biocompatible Stable after implantation Non-migratory Resistant to phagocytosis Pliable - flexible maintain its volume without being absorbed or degradaed minimal foreign body reaction - 4 characters not require pretesting painless inexpensive

    5. What is liquid Injectable Silicone? What is liquid Injectable Silicone? - Silicone is a artificial substance made from silicon, which is used to make polished and also used in cosmetic surgery and plastic surgery- (The scientific name for liquid silicone is dimethylpolysiloxane. Siloxanes are compounds in which the elements silicon is conjugated with oxgen and methane.

    6. What is liquid Injectable Silicone? They can exist as solids, gel, and liquids. -The Viscosity of silicone fluids- (The viscosity of these compounds is a function of the polymerization and cross-linking of their molecule)

    7. What is liquid Injectable Silicone? The viscosity of silicone is measured in centistokes.

    8. Pros and Cons of using silicone Pros 1) Permanent, noncarcinogenic,Minimally antigenic and not support bacterial growth 2) Different forms of silicone implanted into different anatomical sites have differing potential for benefits and complications. Cons 1) Misuse, Adulteration, Substitution. 2) No standard.

    9. Pros and Cons of using silicone Cons 1) Misuse, Adulteration, Substitution. 2) No standard.

    10. History of Silicone In the Past - Many misuse case – ( Large amount of silicone : 1960s U.S ?Contamination ) ( Adulteration by various formula : Sakarai Formula ?mixed with olive oil to increase inflammation and prevent migration)

    11. Formal & Ongoing Study Test small volume of silicone with normal people? No side effects Test large volume of Silicone (21CC)with lipodystrophy ? Severe side effects (facial necrosis,panniulitis) The test is getting sophisticated and rigorous designed. Use 1000-cS fluid

    12. Complications and Immune response Very low frequency (1~2%)of Complications & Bad immune response (Edema, Cellulitis, etc) If the Silicone is injected properly. Fatal results (Death, Siliconoma, etc )can be occurred, If the silicone is injected improperly (Large volume, Industrial Silicone, Unpurified Silicone )

    13. Technical Consideration Injection Technique (1) Must be small amount approximately 0.01 ml (2) Overcorrection should be avoided (3) Material should be placed in the deep dermal or subdermal plane Microdroplet Method : Using tiny droplets of silicone(0.01 to 0,03cc)that are deposited into the subcutis by a series of injection spaced approximately 2 to 10 mm apart.

    14. Consideration ? Silicone Silicone has relatively stable, safe, biocompatible properties in itself as a filler. If the liquid silicone injected improperly ( misuse, Adulteration, Substitution ), the side effects would be occurred.

    15. Consideration ? Other Fillers Host defense mechanisms react differently to the various filler materials, but all substance appeared to be safe . Because the use of a regulated U.S FDA approved product have been shown to cause early side or adverse effects in a very small percentage of patients. But the mechanism of late inflammation or granuloma formation is still unknown. So the chance of its late side effect problems exists.

    16. Conclusion 1. Proper filler injection and Development of surgery techniques. - Usage of Nonpermanent filler (Temporary fillers) - the development of medical appliances.

    17. Conclusion 2. Material technique development of Fillers. 1) Interaction with an energy source and Immunological progression of Filler substances. - Silicone embedded with a chromophore. 2) Adipose derived stem cells as a Filler.

    18. Conclusion 3. The late reactions to filler substances can be verified in exact clinical long – term studies.

    19. Reference 1. An Overview of Permanent and Semipermanent Fillers. 2006 2. Liquid Injectable Silicone : A Review of Its History, Immunology, technical Consideration, Complications, and Potential. 2006 3. Adipose-Derived stem and Progenitor Cells as Fillers in Plastic and Reconstructive Surgery. 2006 4. Liquid injectable silicone for soft tissue augmentation. 2006

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