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ASSOCIATED OF INFLAMMATORY MARKERS WITH SUBCLINICAL ATHEROSCLEROSIS IN TYPE 2 DIABETES

ASSOCIATED OF INFLAMMATORY MARKERS WITH SUBCLINICAL ATHEROSCLEROSIS IN TYPE 2 DIABETES. Caparevic Z, Kostic N, Ilic S, Dekleva M, Pencic B, Radojkovic I . University Clinic for Internal Medicine, CHC "Dr Dragiša Mišovi ć " Department of Endocrinology

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ASSOCIATED OF INFLAMMATORY MARKERS WITH SUBCLINICAL ATHEROSCLEROSIS IN TYPE 2 DIABETES

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  1. ASSOCIATED OF INFLAMMATORY MARKERS WITH SUBCLINICAL ATHEROSCLEROSIS IN TYPE 2 DIABETES Caparevic Z, Kostic N, Ilic S, Dekleva M, Pencic B, Radojkovic I. University Clinic for Internal Medicine, CHC"Dr Dragiša Mišović" Department of Endocrinology School of Medicine, University of BELGRADE, SERBIA AND MONTENEGRO

  2. Background • Accumulation, aggregation and oxidative modification of LDL are believed to play an important role in activation of inflammation. • Oxidized LDL (OxLDL) is associate with the proinflammatory C-reactive protein (CRP) suggested risk factors for atherosclerosis development. • Increased carotid intima-media thickness (IMK) is a surrogate marker of an early atherosclerosis

  3. Aim • The aim of this study was to estimate relations between oxidized LDL (OxLDL), C-reactive protein (CRP) and common carotid intima-media thickness (IMT) in type 2 diabetic patients without coronary heart disease (CHD).

  4. Methods – Studied patients • 44 well controlled type 2 diabetic patientswithout CHD. • The control group was 27 healthy subjects.  None of the patients had a history of cerebrovascular or ischemic heart disease.  They were not treated with any other drugs except oral antidiabetics.

  5. Methods-Biochemical measurements • Lipids profiles were measured by enzymatic methods. • OxLDL was determined by a commercially available sandwich ELISA (Mercodia). • Hs-CRP was measured using hemiluminiscent methods (Immulite-DPC). • HbA1c was measured by immunoturbidometric method using commercialy available kit (Roche). • Glucose were determined by enzymatic methods. • Common carotid artery intima-media thickness (IMT) was measured by ultrasonography (Hewlett Packard Image Point).

  6. Results-Clinical parameters in diabetic patients and controls

  7. Results-Clinical parameters in diabetic patients and controls *p<0,05 ; **p<0,001

  8. Levels of OxLDL was significantly increased in diabetic patients compared to those of controls P<0.05

  9. Levels of CRP was significantly increased in diabetic patients compared to those of controls P<0.05

  10. Correlation analysis revealed a significant positive correlation between LDL and OxLDL

  11. Correlation analysis revealed a significant positive correlation between CRP and OxLDL

  12. Correlation analysis revealed a significant positive correlation between Tg:HDL and OxLDL

  13. Conclusion • The results from our study showed that elevated levels of circulating oxLDL and CRP are associated with an early atherosclerosis developmentin type 2 diabetes. • The study authors also concluded that CRP and OxLDL measurements tended to identify different high-risk groups and that screening for both markers provided better prognostic information than screening for either alone.

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