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Parkinson’s Disease

Parkinson’s Disease. Introduction. Second most common human neurodegenerative disorder. Prevalence of 1 out 272 in U.S. Increases to 4 to 5% for ages 85 and over. Degeneration of dopaminergic neurons in the substantia nigra. Wrote an Essay on the “Shaking Palsy.”. Symptoms.

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Parkinson’s Disease

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  1. Parkinson’sDisease

  2. Introduction Second most common human neurodegenerative disorder. Prevalence of 1 out 272 in U.S. Increases to 4 to 5% for ages 85 and over. Degeneration of dopaminergic neurons in the substantianigra.

  3. Wrote an Essay on the “Shaking Palsy.”

  4. Symptoms Four Cardinal Signs T remor R igidity A kinesian and bradykinesia P ostural instability

  5. Pathogenesis Four theories are given: • Oxidative damage • Environmental toxins • Genetic mutations (LRRK2, PARK2, PARK7, PINK1, SNCA and other unidentified genes) • Accelerated aging

  6. Diagnosis • No definitive tests for PD. PET scans can aid to determine levels of dopamine. • Difficult to diagnose, many symptoms shared with other disorders. • Medical history and neurological tests are conducted to diagnose. • Usually, if two of the cardinal symptoms are present.

  7. Treatment • Physical Therapy • Drug Therapy • Surgery

  8. Role of Biotechnology in Parkinson’s disease: • Stem cell therapy • Gene therapy • Diagnostic marker

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