390 likes | 498 Views
Chapter 28 Urologic Management of Women with Sexual Health Concerns. Carrie Fitzgerald Uro1 2/25/09. Classification Epidemiology Diagnosis Treatment Summary Questions. Sexual Medicine: Theory . Multidisciplinary groups/centers Holistic care Men, women, couples
E N D
Chapter 28Urologic Management of Women with Sexual Health Concerns Carrie Fitzgerald Uro1 2/25/09
Classification Epidemiology Diagnosis Treatment Summary Questions
Sexual Medicine: Theory Multidisciplinary groups/centers Holistic care Men, women, couples Urologist have a unique understanding pelvic floor Improved evidence based management of biologic-based pathophysiologic processes
Classification Women's Sexual Interest/Desire Disorder Subjective Sexual Arousal Disorder Genital Sexual Arousal Disorder Combined Genital and Subjective Arousal Disorder Persistent Sexual Arousal Disorder Women's Orgasmic Disorder Dyspareunia Vaginismus Sexual Aversion Disorder
Classification No accepted screening tool Definition Female Sexual Dysfunction (FSD) not universal Few population-based epidemiologic studies
Epidemiology: Prevalance Sexual desire Lubrication/dryness Pain (after/during) Anorgasmic/difficulty Desire, arousal, orgasm OR pain Current 7% time of report, 31% lifetime 19-23% lifetime 17-19% lifetime 10-20% clinic 4-41% lifetime 33- 35% lifetime 45% (Weijmas Schultz 2005)
Diagnosis • Hx; medical • Neurologic, urologic, gyn • Medications ie SSRI and hormones • Hx; psychologic • Abuse, beliefs, trauma, psych hx, substance abuse • Questionnaires; Female Sexual Function and Sexual Function Questionnaire
Diagnosis: Physical exam Pt directed, anatomy, pain, trauma External genital Glands; ie: minor vestibular adenitis Anal tone, bulbocavernosal reflex Pelvic floor hypertonicity Organ prolapse +/- speculum exam
Diagnosis Work up continued Endocrine disorders ie: thyroid disease, prolactinoma, Addisons disease Skin ie herpes, psoriasis, spider veins
Diagnosis: Labs pH (3.5-4.5) low (candidiasis) high vaginitis, vaginosis, atrophy Wet mount (>1 WBC per epithelial); cx: trichomonas, candida, gonorrhea, chlamydia, herpes, PID Increased parabasal cells: inflammation. Low estrogen Clue cells: bacterial vaginosis
Diagnosis: Labs Androgens ie DHEAS or calculated free testosterone Estrogens LH, FSH, prolactin, TSH +/- SHBG
Diagnosis: Con’t Vascular Neurologic duplex Doppler ultrasonography MRI pelvic/brain Motor innervation Sensory innervation Quantitative Sensory Testing ie thermal/vibratory Clinical research: bulbocavernosal reflex test, somatosensory, electromyography, nerve conduction
Treatment: premenopausal • Estrogen and progesterone ie. OCP or dysmenorrhea treatment • Decrease LH, FSH • Increase SHBG • Therefore decrease testosterone • Monitor levels in sexual dysfunction (SHBG, androgens)
Treatment: premenopausal • DHEA- dietary supplement • limited evidence (arousal, interest, thoughts) • Monitor LFT’s, HDL, estradiol, estrone, acne, hirsurtism
Treatment: premenopausal • Low testosterone • Hyperprolactinemia • Adrenal insufficiency • OCP • Aging (slow progessive) • Limited basic science studies • Limited clinical studies • Limited longterm safety data (esp preg)
Peri/postmenopausal Cessation of estradiol Androstenedione estrone or testosterone estradiol Glycogen glucose lactic acid Tissue atrophy, loss of rugae, decreased lubrication/sensation LUTS, incontinence Increase vaginal pH promotes growth yeast
Peri/postmenopausal- treatment Local Estrogen therapy Systemic estro/progest therapy Tablets (25-hydroxy-17B-estradiol) Ring (2mg estradiol) Cream (conjugated equine estrogen, estradiol, estrone) Dennerstein et al 1980 Ethinyl estradiol 50 microgr Improved vaginal atrophy, dryness, orgasmic freq, desire, enjoyment, mood
Peri/postmenopausal-Treatment • Low Androgens • Mm wasting • Sexual dysfunction • Osteoporosis • Decreased mood, energy, libido
Peri/postmenopausal-Treatment DHEA Testosterone Baulieu et al (2000) DHEA (50 mg) or placebo N= 140 age 60-79 Increased skin hydration Increased bone density Increase libido 6 mo Increase sex satisfaction/ activity 12 mo Shifren et al (2000) s/p oophorectmy on estro Transdermal testosterone (150 UG, 300UG, placebo) Safety; 12 wk; lipids Simon et al (2004) Double blind, 24 weeks Transdermal testosterone (300 UG, placebo) Improved desire, arousal, pleasure, body image, freq
Dopamine Agonists • Premenopausal studies • Caruso (2004) Apomorphine/Placebo control study; enhanced frequency, orgasm, enjoyment • SE: headache
Treatment- Vasodilators Phosphodiesterase type 5 inhibitors Phosphodiesterase type 5 inhibitors • Double blind, crossover safety/efficacy; enhanced arousal, frequency, orgasm, enjoyment • Caruso et al (2001) -premenopausal • Bermann et al (2003)- post menopausal;, benefit in sexual arousal disorder; No benefit in hypoactive desire • SE: headache, nausea, visual changes Psychotropic induced Salerian et al (2000) – SSRI less improvement Nunberg et al (1999) – treats anorgasmia Other vasodilator studies L-arginine, yohimbine, phentolamine, PG E1 Preliminary results
Gential Sexual Pain disorders Phimosis/balantitis Conservative; topical estrogen and/or testosteron Antifungal (po/topical), anti viral , clobetasol if assc with lichen planus/sclerosis Preputial infxtn Sebaceous cysts; abx, sitz bathes and/or I and D Vulvodynia Vulvar hygiene, holistic, amitryptyline/gabapentiv
Genital sexual pain disorders Traumatic neuropathy Irritative voiding symptoms Childbirth Pelvic fractures Saddle injuries Treatment: amitryptyline or gabapentin Urethral prolapse/skenes adenitis Hypoestrogen state Dysuria & perineal burning Urethritis/UTI Cystocele/rectocele Inflammatory gyn condtns Interstitial cystitis
Pelvic floor disorders • Pelvic exam • Hypotonus ie. Childbirth/radiation • Tx Pelvic floor strengthening, TVT, sling • Hypertonus ie. Hypersensitivity disorders • Chr bacterial cystitis • Pain disorders • Urg/freg syndrome • Interstitial cystitis Tx Pelvic floor rehab, massage
Vestibulitis syndrome • Vestibular adenitis dysparunia (<50 yo) • Dysparunia • Conservative: education, top estrogens/lidocaine, TCA, gabapentin • Surgical options • Vulvar vestibulectomy • Complete vulvar vestibulectomy • Modified vulvar vestibulectomy • Vestibuloplasty • Excision of vestibular adenitis
Woodruff (1981) excised a semicircle perineal skin • Posterior hymenal ring • Post vulvar vestibule • Vaginal flap advancement
Other surgical procedures • Dorsal slit for phimosis • Incision/drainage/ mass resection • Vestibulectomy for introital stenosis • Resection of urethral prolapse • Marsupialization of Bartholin cyst • Labioplasty for pain/persistent fungal infections