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TRF1 D/D -LT-Cre

Martinez_5435_Supplementary Fig 1A-C. Wildtype-LT-Cre. Wildtype-LT-Cre. TRF1 D/D -LT-Cre. TRF1 D/D -LT-Cre. A. B. p<0.0001. n=2 MEF 21 cells. 100. p<0.0001. p<0.0001. 100. p<0.0001. 80. n=2 MEF 246 cells. 80. 60. Cells with > 4 TIFs (%). 60. p=0.1.

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TRF1 D/D -LT-Cre

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  1. Martinez_5435_Supplementary Fig 1A-C Wildtype-LT-Cre Wildtype-LT-Cre TRF1D/D -LT-Cre TRF1D/D -LT-Cre A B p<0.0001 n=2 MEF 21 cells 100 p<0.0001 p<0.0001 100 p<0.0001 80 n=2 MEF 246 cells 80 60 Cells with > 4 TIFs (%) 60 p=0.1 53BP1 positive cells (%) p=0.04 p=0.07 n=2 MEF 195 cells 40 n=2 MEF 17 cells 40 n=2 MEF 226 cells n=2 MEF 189 cells n=2 MEF 15 cells n=2 MEF 179 cells n=2 MEF 156 cells 20 n=2 MEF 13 cells 20 0 0 NT NT ATMi (KU55933) caffeine NT ATMi (KU55933) caffeine C Wildtype-LT-Cre TRF1D/D -LT-Cre 53BP1 + Tel

  2. Martinez_5435_Supplementary Fig 2A,B

  3. Wildtype-LT-Cre TRF1D/D-LT-Cre TIN2 TRF1 TRF2+ TRF1 TRF2+ TRF1 TIN2 +TRF1 POT1+ TRF1 POT1+ TRF1 Martinez_5435_Supplementary Fig 3A-D A B Wildtype-LT-Cre TRF1D/D-LT-Cre C D

  4. Martinez_5435_Supplementary Fig 4A-C

  5. Martinez_5435_Supplementary Fig 5A,B

  6. Martinez_5435_Supplementary Fig 5C-F C D E F

  7. Martinez_5435_Supplementary Fig 6A,B

  8. Martinez_5435_Supplementary Fig 7

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