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Event-Related fMRI to Guide rTMS

Event-Related fMRI to Guide rTMS. A. Min Kang Randall R. Benson Margaret Greenwald. Stroke & Aphasia. Stroke is 3 rd -leading cause of death ~700,000 strokes/year in the US ~ 1/4 have language impairments Current treatments: Spontaneous recovery Speech therapy. Goals.

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Event-Related fMRI to Guide rTMS

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  1. Event-Related fMRIto Guide rTMS A. Min Kang Randall R. Benson Margaret Greenwald

  2. Stroke & Aphasia • Stroke is 3rd-leading cause of death • ~700,000 strokes/year in the US • ~ 1/4 have language impairments • Current treatments: • Spontaneous recovery • Speech therapy

  3. Goals • Identify linguistic network functionally. • Target rTMS to this network. • Assess for changes in the functional network, and more importantly, clinical improvement.

  4. Stimuli • 4 types of events: • Same/Different Judgment: • Non-words (VCV - manner, place, voicing) • Notes • Sinewave Combos • Silence • Presented over headphones • Triggered by MRI • Button-box response • Software: Presentation

  5. Event-Related fMRI • TR=8000 Delay in TR=6000 • TE=50 Flip Angle=90 • Slices=27 Thickness=5mm FOV=240mm • # Measurements=52

  6. NW vs. Silent

  7. Notes vs. Silent

  8. NW vs. Notes

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