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The Institutes at the NIH: NHLBI

The Institutes at the NIH: NHLBI. Keith A. Horvath, MD Director, Cardiothoracic Surgery Research Program, NHLBI, NIH Chief, Cardiothoracic Surgery, NIH Heart Center @ Suburban Hospital, Bethesda, MD. NHLBI. Study Section. You. History of the NHLBI.

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The Institutes at the NIH: NHLBI

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  1. The Institutes at the NIH: NHLBI Keith A. Horvath, MD Director, Cardiothoracic Surgery Research Program, NHLBI, NIH Chief, Cardiothoracic Surgery, NIH Heart Center @ Suburban Hospital, Bethesda, MD

  2. NHLBI Study Section You

  3. History of the NHLBI • 1948 - Truman signs the National Health Act, creating the NHI • 1949 - NHI Intramural Research Program • 1969 - Redesignated the NHLI • 1976 - “Blood” added

  4. Historical NHLBI Trials • 1950 - Combine with AHA to sponsor conference • 1972 - Nat’l High BP Education Program • 1981 - Beta-Blocker Heart Attack Trial • 1983 - Coronary Artery Surgery Study • 1984 - Lipid Research Prevention Trial • 1985 - Thrombolysis in MI Trial • 1990 - Human Gene Therapy • 1991 - Studies of LV Dysfunction Trial • 1995 - Bypass Angioplasty Revasc Initiative

  5. Historical NHLBI Trials • 1999 - ARDS Network Study • 1999 - Early Revascularization for Cardiogenic Shock • 2001 - Nat’l Emphysema Treatment Trial • 2001 - REMATCH Trial • 2004 - Sudden Cardiac Death in HF Trial • 2006 - SHOCK Trial • 2007 - Occluded Artery Trial (OAT) • 2008 - Cardiothoracic Surgery Research Network

  6. NHLBI Clinical Trials • EAST • Infant Heart Surgery: Neuro/HCA • CABG Patch Trial • SHOCK Trial • Influence of CPB Temperature on CABG Trial • REMATCH Trial • Tx of Post CABG Depression Study • NETT Surgical Trials 1994-2009

  7. NHLBI Clinical Trials • BARI 2D $ 59 M • Surgical Treatment for Ischemic HF $ 37 M • FREEDOM $ 18 M • CT Surgery Research Network $ 18 M • Moderate Ischemic Mitral Regurgitation • Severe Ischemic Mitral Regurgitation • Surgical Ablation for the Treatment of AF • Post Cardiac Surgery Infection Registry Surgical Trials active

  8. Michael Laurer, Director Diane Bild, Deputy Director Paul Sorlie, Branch Chief Nancy Geller, Director Lawrence Fine, Branch Chief Division of Prevention & Population Sciences (DPPS) Office of the Director Epidemiology Branch Office of Biostatistics Research Clinical Applications & Prevention Branch Women’s Health Initiative Branch Jacques Rossouw, Director

  9. Sonia Skarlatos, Acting Director Dennis Buxton, Branch Chief Marissa Miller, Deputy Branch Chief Michael Domanski, Branch Chief Ahmed Hasan, Acting Deputy Branch Chief Gail Pearson, Branch Chief Charlene Schramm, Deputy Branch Chief Alice Mascette, Branch Chief David Lathrop, Deputy Branch Chief Eser Tolunay, Acting Branch Chief Division of Cardiovascular Diseases (DCVD) Office of the Director Advanced Technologies & Surgery Branch Atherothrombosis & Coronary Artery Disease Branch Heart Developmental & Structural Diseases Branch Heart Failure & Arrhythmias Branch Vascular Biology & Hypertension Branch

  10. W. Keith Hoots, Director George Nemo, Acting Deputy Director Harvey Luksenburg, Chief Rebecca Link, Acting Chief Simone Glynn, Chief Division of Blood Diseases and Resources (DBDR) Office of the Director Blood Diseases Branch Thrombosis and Hemostasis Branch Transfusion Medicine and Cellular Therapeutics Branch

  11. James Kiley, Director Gail Weinmann, Deputy Director Thomas Croxton, Chief Dorothy Gail, Chief Michael Twery, Director Division of Lung Diseases (DLD) Office of the Director Airway Biology and Disease Branch Lung Biology and Disease Branch National Center on Sleep Disorders Research

  12. Rob Fulwood, Acting Director Karen Donato, Acting Chief Diane Striar, Acting Chief Rob Fulwood, Acting Chief Division for the Application of Research Discoveries (DARD) Office of the Director Enhanced Dissemination and Utilization Branch Health Communications and Social Marketing Branch Research Translation Branch

  13. Stephen Mockrin, Director John Taylor, Director Kathyrn Valeda, Director Paul Velletri, Director Suzanne White, Director Robert Musson, Director Division of Extramural Research Activities Office of the Director Office of Acquisitions Office of Committee Management Office of Extramural Policy and Review Office of Grants Management Office of Strategic and Innovative Programs

  14. NHLBI Intramural Research • Translational Medicine Branch • Hematology Branch • Pulmonary and Vascular Medicine Branch • Cardiothoracic Surgery Research Program • Laboratories • Animal Medicine and Surgery • Biochemistry and Biophysics • Cell Biology and Physiology • Genetics and Development • Immunology

  15. University of Pennsylvania Philadelphia, PA

  16. NHLBI Obligations by Funding Mechanism: FY 2009 * Excludes funds provided by other agencies by means of a reimbursable agreement. † Includes $76,341 for Small Business Innovation Research (SBIR) Grants/Small Business Technology Transfer Grants (STTR). ‡ Research Career Programs are a subset of Other Research Grants and are not added as a distinct funding mechanism. § Excludes OD and DIR research contracts, which are included in R&D contracts.

  17. NHLBI Total Obligations by Budget Category: Fiscal Years 1999-2009 Current Dollars

  18. NHLBI Competing Research Project Grant Applications*: Fiscal Years 1999-2009 * Includes R01, R03, U01, P01, R15, R21, R29, and R37; R33 beginning in 2001; DP2 and U19 beginning in ’07; and DP1 and R00 beginning in ’08.

  19. Percent of Reviewed Applications Funded 22%

  20. Resources • Web Home www.nhlbi.nih.gov • Fact Book www.nhlbi.nih.gov/about/factpdf.htm

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