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Bioinformatics at the NIH

Bioinformatics at the NIH . Cheryl Kraft, M.S. Purdue Cyberinfrastructure Days December 9, 2010. National Institutes of Health.

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Bioinformatics at the NIH

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  1. Bioinformatics at the NIH Cheryl Kraft, M.S. Purdue Cyberinfrastructure Days December 9, 2010

  2. National Institutes of Health • The National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services, is the primary Federal agency for conducting and supporting medical research. • NIH is made up of 27 Institutes and Centers, each with a specific research agenda, often focusing on particular diseases or body systems. • The NIH invests over $32.2 billion annually in medical research. • NIH is the largest source of funding for medical research in the world. • NIH leadership and staff play an active role in shaping the agency's activities and outlook.

  3. Top 5 Institutes by Funding FY11 • National Cancer Institute (NCI) - $5.2 B • National Institutes of Allergy and Infectious Diseases (NIAID) - $4.9B • National Heart, Lung and Blood Institute (NHLBI) - $3.1B • National Institute of General Medical Sciences (NIGMS) - $2.1B • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) - $2B Source: http://dhhs.gov/asfr/ob/docbudget/2011budgetinbrief.pdf

  4. NIH Priorities • Genomics: Science-driven increases in genomics and other high-throughput technologies in FY 2011 will support a range of bold and innovative efforts against cancer and autism. • Cancer: In FY 2010 the NIH began to invest over $6 billion for cancer research across NIH, reflecting the first year of an eight-year strategy to double cancer research by FY 2017. • Autism: In FY 2010 the NIH budget included $141 million for research into the causes of and treatments for autism spectrum disorders (ASD).

  5. NIH Priorities continued • NIH Common Fund: An incubator for new projects that can overcome complex research barriers and accelerate the pace of discovery for new disease treatments, prevention strategies, and diagnostics across all Institutes and Centers. • New Investigators: Stem the trend of increases in the average age of first-time principal investigators obtaining independent research funding from NIH. NIH is aiming to have similar success rates between new investigators and new applications from established principal investigators. • Clinical Research Translation: NIH developed a new Clinical and Translational Science Award (CTSA) beginning in FY 2006. These awards help advance information technology, integrate research networks, stimulate the development of computer-assisted outcome measurement, and improve workforce training. (NCRR)

  6. Bioinformatics Priorities • Subject privacy and anonymity. • Data sharing, data interoperability. • Ontologies, ie standard phenotypes. • Novel tool development. • Analysis • Visualization • Prediction • Reuse and secondary analysis of data to produce novel findings. • Multi-scale modeling of disease process and human immune system.

  7. Innovations in Biomedical Computational Science and Technology– PAR-09-218 • Investigators may target one or multiple areas of biomedical computing that will enable progress in biomedical research. • genomic sequences, gene expression, proteomics, pathway data, scientific and biomedical images, qualitative descriptors for health and social science, and remote sensing and geospatial images.

  8. Innovations in Biomedical Computational Science and Technology– PAR-09-218 • Tools for data acquisition, archiving, querying, retrieval, visualization, integration and management. • Platform-independent translational tools for data exchange and for promoting interoperability. • Analytical and statistical tools for interpretation of large data sets. • New models or simulations of complex biological processes at single and multiple levels or across multiple scales (and the development of computational and/or mathematical tools for the analysis of these processes).

  9. RFA-RM-10-010 • NIH Common Fund Transformative Research Projects Program • Groundbreaking • Exceptionally innovative • High risk • Original and/or unconventional research with the potential to create new scientific paradigms or challenge existing ones

  10. What are they looking for? • Innovation, innovation, innovation • Team science, cross disciplinary teams • Broad applicability • Well written proposal • Clearly described concepts • Specificity

  11. Informatics grants at NIH • FY 2010 – 1579 grants and contracts awarded. • FY 2009 – 1767 grants and contracts awarded. • FY 2008 – 1329 grants and contracts

  12. Top Institutes funding informatics in FY10 • NCI • NCRR • NLM • NIGMS • NHLBI

  13. Some current programs at NIAID

  14. Resources Abound • www.nih.gov • www.bisti.nih.gov • Funding Opportunities related to NIAID available at: http://www.niaid.nih.gov/ncn/budget/opps.htm

  15. Resources Abound • Public resources for research content • www.immport.org • www.immunepitope.org • www.systemsimmunology.org

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