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Prenatal and Postnatal Growth and Endocrine Diseases

Francesco Chiarelli is Professor of Pediatrics and Pediatric Endocrinology at the Department of Pediatrics, University of Chieti, Italy His field of research is diabetes mellitus in children, with reference to early detection and prevent

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Prenatal and Postnatal Growth and Endocrine Diseases

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    1. Prenatal and Postnatal Growth and Endocrine Diseases Francesco Chiarelli

    3. 1. Definition and causes of IUGR 2. Growth and growth factors 3. Insulin-resistance 4. Adrenals 5. Gonads

    4. 1. Definition and causes of IUGR 2. Growth and growth factors 3. Insulin-resistance 4. Adrenals 5. Gonads

    6. Definition of Small for Gestational Age (SGA) Birth weight and/or length of 2 or more standard deviations (SD) below the mean for gestational age and sex

    9. What are the causes of SGA? Maternal Vascular disease Environmental factors Infection Nutrition

    10. IUGR: phenotypes

    11. 6-8 fold increase for intrapartum and neonatal death Respiratory distress Necrotizing enterocolitis Meconium aspiration Electrolyte imbalance Polycythemia Intraventricular hemorrhage

    13. 1. Definition and causes of IUGR 2. Growth and growth factors 3. Insulin-resistance 4. Adrenals 5. Gonads

    15. Postnatal growth in children born SGA

    19. GH-IGF axis

    26. Reprogramming of the GH-IGF axis in IUGR

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