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Francesco Chiarelli is Professor of Pediatrics and Pediatric Endocrinology at the Department of Pediatrics, University of Chieti, Italy His field of research is diabetes mellitus in children, with reference to early detection and prevent
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1. Prenatal and Postnatal Growth and Endocrine Diseases Francesco Chiarelli
3. 1. Definition and causes of IUGR2. Growth and growth factors3. Insulin-resistance4. Adrenals5. Gonads
4. 1. Definition and causes of IUGR2. Growth and growth factors3. Insulin-resistance4. Adrenals5. Gonads
6. Definition of Small for Gestational Age (SGA) Birth weight and/or length of 2 or more standard deviations (SD) below the mean for gestational age and sex
9. What are the causes of SGA? Maternal
Vascular disease
Environmental
factors
Infection
Nutrition
10. IUGR: phenotypes
11. 6-8 fold increase for intrapartum and neonatal death
Respiratory distress
Necrotizing enterocolitis
Meconium aspiration
Electrolyte imbalance
Polycythemia
Intraventricular hemorrhage
13. 1. Definition and causes of IUGR2. Growth and growth factors3. Insulin-resistance4. Adrenals5. Gonads
15. Postnatal growth in children born SGA
19. GH-IGF axis
26. Reprogramming of the GH-IGF axis in IUGR