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Interpreting Biomarkers in humans

Interpreting Biomarkers in humans. Agency for Toxic Substances & Disease Registry. Continuum for Relating Environmental Contamination with Clinical Disease. Limited number of biomarkers available for human biomonitoring. Heavy metals Organic compounds. Heavy Metal Biomarkers.

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Interpreting Biomarkers in humans

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  1. Interpreting Biomarkers in humans Agency for Toxic Substances & Disease Registry

  2. Continuum for Relating Environmental Contamination with Clinical Disease

  3. Limited number of biomarkers available for human biomonitoring • Heavy metals • Organic compounds

  4. Heavy Metal Biomarkers • Analytic methods are standardized • Good estimate of recent exposure • Reference ranges generally available

  5. Organic Compounds • Volatile Organic Compounds • Persistent Organic Compounds

  6. Biomarkers measure aggregate exposure • All routes • All sources

  7. Reference ranges • Are population-based • Do not relate to health effects

  8. How does one relate measurements in the environment and biota to human measurements ?

  9. PCB’s in Fisherman from 2 contaminated areas

  10. DDT-related compounds in eggs

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