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Note to presenters:

Note to presenters: Images of vaccine-preventable diseases are available from the Immunization Action Coalition website at http://www.vaccineinformation.org/photos/index.asp. Haemophilus influenzae type b Clinical Features*. *prevaccination era. Incidence* of Invasive Hib Disease, 1980-2009.

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  1. Note to presenters: Images of vaccine-preventable diseases are available from the Immunization Action Coalition website at http://www.vaccineinformation.org/photos/index.asp

  2. Haemophilus influenzae type b Clinical Features* *prevaccination era

  3. Incidence* of Invasive Hib Disease, 1980-2009 *Rate per 100,000 children <5 years of age

  4. Haemophilus influenzae type b Epidemiology • Reservoir Human Asymptomatic carriers • Transmission Respiratory droplets • Temporal pattern Peaks in Sept-Dec and March-May • Communicability Generally limited but higher in some circumstances

  5. Haemophilus influenzae type b—United States, 2002-2006 • Incidence has fallen more than 99% since prevaccine era • 123 confirmed Hib cases reported (average of 25 cases per year) • Most recent cases in unvaccinated or incompletely vaccinated children

  6. Haemophilus influenzae type b Conjugate Vaccines • Two conjugate vaccines licensed for use in infants as young as 6 weeks of age • Use different carrier proteins • 3 doses of any combination confers protection

  7. Conjugate Hib Vaccines* PRP-T ActHIB, TriHIBit PRP-T Hiberix PRP-OMP PedvaxHIB, Comvax *HbOC (HibTiter) no longer available in the United States

  8. Haemophilus influenzae type b Vaccine Interchangeability • Both conjugate Hib vaccines (except TriHIBit) are interchangeable for primary series and booster dose • 3 dose primary series if more than one brand of vaccine used

  9. Hiberix (PRP-T) • Approved for children 12 months of age and older • Approved only for the last dose of the Hib series

  10. Haemophilus influenzae type b VaccineVaccination Following Invasive Disease • Children younger than 24 months may not develop protective antibody after invasive disease • Vaccinate during convalescence • Complete series for age

  11. Haemophilus influenzae type b VaccineUse in Older Children and Adults • Generally not recommended for persons older than 59 months of age • Consider for high-risk persons: asplenia, immunodeficiency, HIV infection • One pediatric dose of any conjugate vaccine • 3 doses recommended for all persons who have received a hematopoietic stem cell transplant

  12. Haemophilus influenzae type b Vaccine Adverse Reactions • Swelling, redness, or pain in 5%-30% of recipients • Systemic reactions infrequent • Serious adverse reactions rare

  13. Haemophilus influenzae type b Vaccine Contraindications and Precautions • Severe allergic reaction to vaccine component or following a prior dose • Moderate or severe acute illness • Age less than 6 weeks

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