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Fungal Infections, Pathogenesis and Treatment

Fungal Infections, Pathogenesis and Treatment. Fungal infections. 400 out of 75,000 Primary infections Opportunistic infections Myco -toxins Allergy. Mycoses. Superficial and cutaneous Subcutaneous Deep (systemic). Examples of yeast of medical importance. Candida species

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Fungal Infections, Pathogenesis and Treatment

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  1. Fungal Infections, Pathogenesis and Treatment

  2. Fungal infections • 400 out of 75,000 • Primary infections • Opportunistic infections • Myco-toxins • Allergy

  3. Mycoses • Superficial and cutaneous • Subcutaneous • Deep (systemic)

  4. Examples of yeast of medical importance • Candida species • Cryptococcus neoformans • Malasseziaspecies

  5. Examples of moulds of medical importance • Dermatophytes • Aspergillus species • Zygomycetes

  6. Superficial and CutaneousMycoses • Skin, hair, nail and mucus membranes • Most common • World-wide • Ringworm infections du to Dermatophytes • Yeast infections due to Candida

  7. pityriasisversicolor

  8. pityriasisversicolor Directexamination

  9. Tineanigra

  10. Tineanigra Skin scrapings

  11. Intertrigo caused by Canddia albicans

  12. Dermatophytosis Dermatophytosis caused by M. canisfollowing contact with infectious cat

  13. Dermatophytosis direct skin examination

  14. Dermatophytosis

  15. Fungal nail infection

  16. Subcutaneous Mycoses • Skin, subcutaneous tissues, fascia and bone • Localized • Trauma • More in tropics • Mycetoma, chromomycosis and sporotrichosis

  17. Mycetoma

  18. Mycetoma

  19. Sporotrichosis A 60-year-old woman developed multiple subcutaneous nodules and abscesses on her right hand and forearm 7 days after finger thorn prick

  20. Classical Chromoblastomycosis: Fonsecaea pedrosoi De Hoog,Centraalbureau voor Schimmelcultures

  21. Nodulose chromoblastomycosis (Senegal): Fonsecaea pedrosoi De Hoog,Centraalbureau voor Schimmelcultures

  22. Systemic Mycoses • Deep-seated • Inhalation • Primary (restricted) • Opportunistic (world-wide)

  23. Opportunistic fungal infections • Aspergillosis • Pulmonary • Disseminated • Para nasal sinusitis • Candidiasis • Pulmonary • Candidemia • Cryptococcus meningitis

  24. Polyene antifungal agents • Amphotericin B • Nystatin

  25. Azoles antifungal agents • Clotrimazole • Econazole • Ketoconazole • Miconazole • Fluconazole • Itraconazole • Posaconazole • Voriconazole

  26. Other antifungal agents • Echinocandins • Anidulafungin • Caspofungin • Micafungin • Terbinafine • 5-fluorocytosine

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