1 / 31

Haematology

Haematology. Haemostasis. The involvement of blood vessels, platelets and blood coagulation in haemostasis. Vascular bleeding disorders:. .The underlying abnormalities are either in the vessels themselves perivascular connective tissue . Each could be Inherited Acquired.

mikij
Download Presentation

Haematology

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Haematology

  2. Haemostasis

  3. The involvement of blood vessels, platelets and blood coagulation in haemostasis

  4. Vascular bleeding disorders: .The underlying abnormalities are either in the vessels themselves perivascular connective tissue. Each could be Inherited Acquired

  5. Inheritedvasculardisorders Hereditary haemorrhagictelangiectasia autosomal dominant trait. There are dilated microvascular swellings appear during childhood and become more numerous in adult life. These telangiectasia develop in the skin, mucous membranes and internal organs

  6. Ehlers-Danlos syndrome hereditary collagen abnormalities with purpura resulting from defective platelet aggregation hyperextensibility of joints and hyperelastic friable skin

  7. Acquired vascular defect Simple easy bruising Purpura associated with infections Senile purpra Scurvy The Henoch-Schonlein syndrome Steroid purpura

  8. b a

  9. Henoch –Sconleinsyndrome immune complex (typeIII) hypersensitivity reaction usually found in children often following acute infection The characteristic purpuric rash accompanied by localized edema & itching is often most prominent on the buttocks &extensor surfaces of lower legs & elbows Painful joint swelling, haematuria & abdominal pain may also occur.

  10. Thrombocytopenia

  11. 3-Abnormal distribution of platelets *splenomegaly 4-Dilutional loss *Massive transfusion of stored blood

  12. Hereditary disorders Thrombasthenia (Glanzmann's disease) Bernard-Soulier syndrome Storage pool diseases Acquired disordersAntiplatelet drugs Hyperglobulinaemia Myeloproliferative and myelodysplastic Disorders Uraemia Heparin, dextrans, alcohol and radiographic contrast

  13. Assessment of Coagulation 1.Clinical assessment. 2.Labroratory assessment.

  14. Laboratory assessment of Coagulation: • Bleeding time: • Platelet counts: • Prothrombin time (PT): • Partial thromboplastin time (PTT): • Thrombin time (TT):

  15. Case • A 5 yr old boy presents with a haemarthrosis of the right knee. Coagulation studies show normal PT ,normal bleeding time,normal TT, prolonged APTT . Explain the coagulatin defect?

  16. The defect is in the intrinsic pathway . • Haemophillia A or • Haemophillia B • Factor assay.

  17. Haematoma

  18. DIC

  19. Lab. Findings: • 1 .The platelet count is low. • 2. Fibrinogen concentration low. • 3 .The thrombin time is prolonged. • 4 .High levels of fibrin degradation products such as D -dimers are found in serum and urine. • 5. The PT and APTT are prolonged . •  6. bleeding time is prolonged.

  20. THANK YOU

More Related