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Aim

Intrinsic transient tracheal occlusion training and myogenic remodeling of rodent parasternal intercostal fibers. Barbara K. Smith, PhD, PT; Sunita Mathur, PhD, PT; Fan Ye, MD, PhD; A. Daniel Martin, PhD, PT; Sara Attia Truelson, BS; Krista Vandenborne, PhD, PT; Paul W. Davenport, PhD. Aim

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Aim

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  1. Intrinsic transient tracheal occlusion training and myogenic remodelingof rodent parasternal intercostal fibers Barbara K. Smith, PhD, PT; Sunita Mathur, PhD, PT; Fan Ye, MD, PhD; A. Daniel Martin, PhD, PT; Sara Attia Truelson, BS; Krista Vandenborne, PhD, PT; Paul W. Davenport, PhD

  2. Aim • Investigate myogenic activity and morphological remodeling of parasternal muscle fibers in conscious rats after intrinsic transient tracheal occlusion (ITTO). • Relevance • Weak diaphragm or intercostal muscles results in paradoxical movements between thorax and abdomen and impedes compensatory increases in ventilation during elevated drive.

  3. Method • Conducted 2 experiments in 19 young-adult male Sprague-Dawley rats: • Investigated whether daily sessions of ITTO loading would facilitate fiber hypertrophy and regeneration in parasternal intercostals. • Compared presence of myogenic biomarkers in parasternal intercostals to diaphragm after either ITTO or sham training.

  4. Results • 10 ITTO sessions were associated with increased cross-sectional area of type IIx/b muscle fibers and increased prevalence of Pax7-positive nuclei identified in diaphragm and parasternal intercostal muscles. • Additional fast to slow fiber shift and embryonic myosin heavy chain-positive fibers suggested differences in loading and remodeling of parasternal intercostals.

  5. Conclusion • To provide understanding of mechanisms underlying muscle adaptation for clinical rehabilitation, future studies should: • Address functional transcriptional and translational pathways that accompany respiratory muscle training. • Examine force adaptations of respiratory muscles.

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