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Bilateral differences in lower-limb performance in individuals with multiple sclerosis

Bilateral differences in lower-limb performance in individuals with multiple sclerosis. Rebecca D. Larson, PhD; Kevin K. McCully, PhD; Daniel J. Larson, PhD; William M. Pryor, MS; Lesley J. White, PhD. Aim

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Bilateral differences in lower-limb performance in individuals with multiple sclerosis

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  1. Bilateral differences in lower-limb performance in individuals with multiple sclerosis Rebecca D. Larson, PhD; Kevin K. McCully, PhD; Daniel J. Larson, PhD; William M. Pryor, MS; Lesley J. White, PhD

  2. Aim • Quantify bilateral differences in lower-limb performance and metabolism of people with multiple sclerosis (MS) during exercise. • Relevance • Bilateral differences in lower-limb strength in people with MS have been clinically observed.

  3. Method • Completed bilateral assessments of muscle strength and incremental cycling in: • 8 ambulatory individuals with mild MS. • 7 non-MS controls.

  4. Results • Individuals with MS: • Significant between-leg differences in leg strength, peak oxygen uptake, and peak workload. • Non-MS controls: • No between-leg differences.

  5. Conclusion • Preliminary evidence suggests that magnitude of differences may be related to limitations in aerobic function.

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