Case Investigations in Human Biology and Global Health

1. Case Investigations in Human Biology and Global Health Marion Field Fass Ethel D. Stanley Julie A. Seiter Margaret A. Waterman

2. Pedagogy • Cyberlearning • Data sets • Mapping • Graphing • Videos • Models/simulations • Civic Engagement • Integrative Thinking

3. Health and human rights- Clean water, good food and an educated mother public health; agent host and environment, thinking at the population level Introduction

4. Challenge of human birth: maternal mortality, infant mortality, complications of birthing Graphing, modeling Women’s rights play in the access to care Child health is related to a healthy mom, clean water, safe food, feeding practices. Mothers and babies

5. Double burden of malnutrition, undernutrition and obesity Vitamins and minerals, proteins, fats impact of child nutritional status, dietary choices constrained by poverty, mapping, visual learning- Food The Associated Press Fri., June 19, 2009

6. Blood and its functions, anemia, parasitic disease vs viral disease Oxygen is the terminal electron acceptor concept of vector Humans in environment, genetic changes in vector, pathogen that enable pathogen to reach new “virgin” audiences- Epidemiology, impact of climate change Mosquito diseases

7. HIV, immune system, Biological challenge of Prevention, biology of treatment Identifying factors that create conditions for spread- with HIV these are strikingly social- Epidemiology, global and US, new strategies for prevention HIV

8. TB, lung anatomy and phys, concepts of infectious disease, drugs and drug action, begin resistance Interaction of environment, evolution of pathogen, problems of non-compliance with drugs, DOTS (directly observed therapy), need for new tests Tuberculosis

9. MRSA Bacterial mutation, conjugation Food supply, Hospitals Humans in larger environments Spread of MRSA from hospital to environment now to food sources- Interaction of environment, evolution of pathogen, problems of non-compliance with drugs, antibiotic misuse MRSA and the Rise of Antibiotic Resistance

10. Immunizations- measles, mumps, rubella, but what about HPV? What is global picture? Disease erad- must do smallpox, maybe polio- maybe eradicatable pathogens- The public health part is strategies for disease control- vaccination vs treatment; environmental strategies, reduction of pool of susceptibles (herd immunity) and then loss of fear in populations Disease control and eradication

11. Mutating virus- its not just the developing world Epi, history, mechanisms of control of diseases in populations, mapping and surveillance Influenza

12. Heart physiology, back to genetics, treatments, scope of the problem Oxygen is the terminal electron acceptor Major causes of death in developed world How / when do developing countries catch up? Heart disease

13. Endocrine system Mechanisms of insulin action, resistance to insulin Lots of epidemiology, changes in food and diabetes, long term impact of diseases and burden of Years of Productive Live Lost (YPLL) and DALYs (Disability Associated Life Years) Diabetes

14. CANCER (all cancer is genetic although not all cancer is inherited), heart disease, Lung diseases (COPD) Interaction of smoking and environment and second hand smoke just when we thought everything was OK the industry guys promoted tobacco use Long term impacts of health habits, life table analysis, comparisons globally, role of WHO in this work, industry vs advocates. WHO Convention on Tobacco, international collaboration. bill gates and michael bloomberg think its important Tobacco

15. Human biology, global health and environmental change- the impact of the environment on human physiology and health Measuring on particulates it follows from host –agent- environment Population thinking International efforts to mitigate air pollution Beijing Blue