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KU Alzheimer’s Disease Center— The Executive Director’s Perspective

KU Alzheimer’s Disease Center— The Executive Director’s Perspective. Anne Arthur, BSN, MS, APRN-BC KU Alzheimer’s Disease Center Executive Director www.kualzheimer.org. Objectives. Discuss the history of the KU Alzheimer’s Disease Center (KU ADC)

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KU Alzheimer’s Disease Center— The Executive Director’s Perspective

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  1. KU Alzheimer’s Disease Center—The Executive Director’s Perspective Anne Arthur, BSN, MS, APRN-BC KU Alzheimer’s Disease Center Executive Director www.kualzheimer.org

  2. Objectives • Discuss the history of the KU Alzheimer’s Disease Center (KU ADC) • Identify the accomplishments of the KU ADC since inception • Explore ways the KU ADC can support investigators

  3. History of the ADC • NIA-Division of Neuroscience • Established in 1984 • Goal: promote research network on AD • 29 centers in the US • National meetings twice a year

  4. Alzheimer’s Disease Centers (ADC)—29

  5. Timeline Dr. Jeffrey Burns joins faculty(2004) Dr. Russell Swerdlow joins faculty (2007) KU ADC Funded (1991-1996) ADC application to NIA (2009) ADC resubmission to NIA (2010) KU ADC funded (8/15/2011) NIA establishes ADCs (1984)

  6. KU ADC • Director: Russell Swerdlow • 7 Cores • Aims 1-Support AD, AD-related, and brain aging research projects 2-Provide advanced services that facilitate ground-breaking metabolism research

  7. KU ADC Structure KU ADC-Specific Cores

  8. Administrative CoreLeader: Russell Swerdlow, MD • Goals • Provides oversight to the KU ADC • Promotes AD, MCI and brain aging research • Pilot Program • Resource Request • Expands KUs base of clinical, translational and basic science investigators • Collaborative REsearch Workgroup (CREW) meetings

  9. Advisory Boards Internal Advisory Board Randy Nudo Carol Cleek Joseph Donnelly Paul Terranova Peter Smith Richard Barohn Steven Warren Susan Kemper Robert Krumlauf External Advisory Board Charles DeCarli Angela Jefferson Nigel Cairns Walter Kukull Thomas Montine William Jagust Teresa Radebaugh

  10. Projects Supported • 18 Federal • 2 P01 (Michaelis, Kouhlen) • 7 R01 (Burns, Williams, Berman, Zhu) • 15 Foundation • 5 Training awards • 11 Therapeutic trials • ADCS • Alzheimer’s Drug Discovery Foundation • Pharmaceutical

  11. Clinical CoreLeader: Jeffrey Burns, MD • Goals • Cohort of nondemented, MCI and AD subjects • Support and encourage collaborative interdisciplinary studies • Data • Biological specimens • Clinical research infrastructure • Burns elected to National ADC Steering Committee and ADC Clinical Task Force

  12. Clinical Core • 400 well-characterized participants

  13. Clinical Core Evaluation Clinical Evaluation (CDR) Yearly Visit 1 Memory Testing Visit 2 Yearly Labs/ Physical Function Testing/ DEXA Every 3 years Visit 3

  14. Data Collection • Clinical Evaluation • Clinical Dementia Rating (CDR) Scale • Neurological Exam • Memory testing • Physical Function testing • DEXA scan • Boston Naming Test • Block Design • Stroop • Free and Cued SRT • Letter Number Sequencing • MMSE • Logical Memory I & II • Digit Span Forwards/Backwards • Category Fluency • Trailmaking A & B • Digit Symbol

  15. Specimen Collection • Processed and stored in the Biospecimen Shared Resource (BSR) Center Plasma Buffy Coat Platelets Serum Whole Blood Cell-free Plasma Cybrid Cell Lines DNA RNA

  16. National Alzheimer’s Coordinating Center (NACC) • Established by NIA in 1999 • Support all ADCs • Database for clinical and neuropath data • Partners • National Alzheimer’s Disease Cell Repository (NCRAD) • Alzheimer’s Disease Genetics Consortium (ADGC) • Free to investigators

  17. Data/Specimen Sharing KU ADC Clinical and Cognitive data DNA National Alzheimer’s Coordinating Center (NACC) National Cell Repository for Alzheimer’s Disease (NCRAD)/Alzheimer’s Disease Genetics Consortium (ADGC)

  18. Data Management and Statistics CoreLeader: Jonathan Mahnken, PhD • Goals • Provide statistical expertise • Develop Data and Information Management and Monitoring Systems • Mahnken elected to NACC Scientific Review Committee 2011-2014 • Present national ADC meeting 10/2012

  19. Neuropathology CoreLeader: Kathy Newell, MD • Goals • Autopsy human brain tissue from Clinical Core participants • Autopsy animal models • Neuropathological consultation and specimen sharing

  20. Scanning and Imaging Aperio Digital Scanning System Nikon Eclipse 80i + Metamorph

  21. Brain Autopsy Program • Clinical Core participants • Demented/non-demented brains • Neuropathology Case Conference • 2nd Thursday odd months, 4-5p, 1605 Surgical Pathology, Microscope Room 2

  22. Education & Information Transfer CoreLeader: Heather Anderson, MD • Goals • Recruit/retain subjects • KU ADC Clinical Core cohort • Clinical Trial Unit (CTU) • Train students and health professionals • Increase awareness of AD and the KU ADC

  23. Recruitment/Retention • Presentations • Newsletters • Social Media • Facebook • Twitter • Electronic newsletter • Birthday Cards • Annual Appreciation Breakfast

  24. Recruitment Sources

  25. Recruitment Flow Ed Core Investigator-Initiated studies Clinical Trial Unit Clinical Core

  26. Education/Outreach • Seminar Series on Health, Aging and Dementia • Partner with LCOA and GPGEC • Alzheimer’s and Aging Research Colloquium • Partner with LCOA and GPGEC • Healthy Aging Symposium • Partner with JCCC • Annual Appreciation Breakfast • Lectures/presentations • Student observership

  27. Neuroimaging CoreLeader: William Brooks, PhD • Goals • Advanced scientific support and subsidized scans for AD research • Advanced training and education in imaging • Develop novel imaging techniques for studies in AD

  28. Hoglund Brain Imaging Center • Instrumentation • 3 Tesla Siemens Skyra human MRI scanner • 9.4T Varian/Agilent animal MRI scanner • PET/CT Scanner (General Electric DST) (including cyclotron CTI (Siemens RDS 111) • 151-channel whole-head CTF MEG unit (including simultaneous 160 channel EEG)

  29. Novel Imaging Techniques • Translation of imaging protocols to new 3T scanner • Glutathione (GSH) spectroscopic imaging sequence • Vitamin C spectroscopic imaging sequence under development • Neurochemical profile from MRS

  30. Mitochondrial Genomics& Metabolism CoreLeaders: Eli Michaelis, MD, PhD & Mary L. Michaelis, PhD • Goals • Prepare mitochondria, protein extracts, DNA, and RNA • Prepare cybrid cell lines • Perform mtDNA sequencing and 8-OH-2-dG measurements • Assist in AD mitochondrial research

  31. Support for Investigators • Pilot Grant Program • Resource Requests • Collaborative REsearch Workgroup (CREW) Meetings

  32. Pilot Grant Program • 3-4 grants awarded annually (July 1st) • Dr. Nudo, Landon COA, funded 1 project yr 1 & 2 • $30,000 awarded/grant • RFA 2nd week in December • New and established investigators eligible to apply • Contact: Eric Vidoni, PhD

  33. Resource Requests • Investigators conducting research on aging, MCI and AD can apply • Consultation • Services • Research materials • http://www.kualzheimers.org/alzheimers-disease-center/researcher-resources/researcher-resource-request.html

  34. Biospecimen Resources • Brain Tissue • Buffy Coat • Cell-free Plasma • Cybrid Cell Lines • DNA • RNA • Muscle • Plasma • Platelets • Serum • Whole Blood

  35. Database Access • Alzheimer’s Disease Neuroimaging Initiative • National Alzheimer’s Coordinating Center • Kansas University Brain Aging Project

  36. Metabolism & Mitochondria Resources • Physical fitness, glucose tolerance, metabolic rate, and body composition testing • Structural brain neuroimaging of humans and animals • Metabolic neuroimaging of humans and animals (FDG PET, AV-45 and MRS) • Biochemical assays • Mitochondria, protein extracts, DNA, and RNA • Cybridcell lines • mtDNAsequencing and 8-OH-2-dG measurements

  37. CREW Meetings • Collaborative REsearch Workgroup (CREW) meetings • 3rd Monday of every month in Clinical Research Center • All investigators in aging and dementia welcome to attend

  38. How you can help • Refer study participants • Collaborate with us • Spread the word • Cite us • Complete REDCap survey for any KU ADC-affiliated publications, presentations, etc. https://redcap.kumc.edu/surveys/?s=Tpmj5i

  39. KU ADC Team Administrative Core Russell Swerdlow, MD Jeffrey Burns, MD Anne Arthur, APRN Eric Vidoni, PhD Brad Amstein, BS Clinical Core Jeffrey Burns, MD Anne Arthur, APRN Russell Swerdlow, MD Heather Anderson, MD David Johnson, PhD Phyllis Switzer Hilary Dubinsky, BS Diane Cunningham Ashley Thompson Education and Information Transfer Core Heather Anderson, MD Angela Van Sciver Mitochondrial, Genomics and Metabolism Core Eli Michaelis, MD, PhD Mary Lou Michaelis, PhD Russell Swerdlow, MD Xinkun Wang, PhD Data Management and Statistics Core Jonathan D. Mahnken, PhD Hung-Wen (Henry) Yeh, PhD Russ Waitman, PhD BhargavAdagarla, MS Suzanne Hunt, MS Cathy Price, BS Mani Nair, MS, MBA Megan Parks, AA Dan Connolly, BS Alexandra Brown, BS Neuropathology Core Kathy Newell, MD Cynthia Gouvion Neuroimaging Core William Brooks, PhD In-Young Choi, PhD, MR Phil Lee, PhD, MR Laura Martin, PhD Cary Savage, PhD RegDusing, MD

  40. How to Contact KU ADC KU Alzheimer’s Disease Center (913) 588-0555 kuamp@kumc.edu www.kualzheimer.org Research Requests http://www.kualzheimers.org/alzheimers-disease-center/researcher-resources/researcher-resource-request.html Data Core http://biostatistics.kumc.edu

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