1 / 64

Chemotaxis of Eucaryotic Cells

Chemotaxis in Dictyostelium Discoideum. The dictyostelids are a group of cellular slime moulds. When food (normally bacteria) is readily available they take the form of individual amoebae, which feed and divide normally. However, when the food supply is exhausted, they aggregate to form a multicell

miriam
Download Presentation

Chemotaxis of Eucaryotic Cells

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

    1. Chemotaxis of Eucaryotic Cells

    2. Chemotaxis in Dictyostelium Discoideum

    3. Der slime mould Dictyostelium Discoideum

    4. Developmental Cycle of D. Discoideum

    5. The Life-Cycle of Didi

    6. Chemotaxis in Dictyostelium Discoideum

    7. Dicties move "stochastic" without c-AMP stimulation

    8. Eukaryotic Chemotaxis

    9. Modes of Signalling

    10. The messenger c-AMP

    11. Directed locomotion induced by c-AMP gradients

    12. G-Protein-coupled receptors transmit the signal intracellularly by trimeric G-Proteins, which then change the concentration of intracellular „second messengers“.

    13. Activation of Receptor couples to Adenylylcyclase

    14. Biochemical Network of Cell aggregation

    15. Cell-Aggregation by c-AMP Stimulus

    17. Modular view of the chemoattractant-induced signaling pathway in Dictyostelium

    20. Inositol Phospholipid Signalübertragung

    21. PIP3 acts as internal compass

    23. The Inositol Phospholipid Signal Pathway

    27. Actin Polymerization at the front

    28. Polarisation Change of cell shape by activation of the cytosceleton

    29. Biochemical Network of Cell aggregation

    30. Models to explain chemotaxis

    31. The chemotactic polarization is persistent

    32. Local activation - Global inhibition

    33. Switching on and off the c-AMP Stimulation

    34. Modelling the intracellular messenger distribution

    35. Numerical solutions of the differential equations

    36. Simulation Results

    37. Chemotaxis

    38. Zell motility is driven by Actin

    40. Cell Aggregation

    41. c-AMP Waves in Aggregating Cells

    42. Video Cell Aggregation

    43. Biochemical Network of Cell Aggregation

    45. Autocatalytic Oscillators

    46. Der Van der Pol Oscillator

    47. Solving the Van der Pol Equation

    48. The allosteric control of enzyme activity

    49. Reprise

    50. Model of Goldbeter&Segel

    51. Approximations of the Goldbeter Equation

    52. Solving the Goldbeter Model

    53. Observation: Spontaneous c-AMP Oscillations

    55. Biochemical Network of Cell aggregation

    56. Choice of kinetic constants and results of simulation

    57. Influence of a c-AMP spike on the phase of the oscillation

    58. Phase Shift by adding cAMP

    60. Robustness of the biochemical network

    61. The cyclic phosphorylation of the kinase ERK2

    62. Simulation of Aggregation

    63. The Theory cellular Automata

    64. Simulation result of a simple dynamics

More Related