Toxicity Testing

Jun 23, 2013

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Cycle of Response to Toxics. Toxic effect of one substance documented. Public response/ outcry. Legislation to regulate toxic effects. More studies of other chemicalsImproved analytical accuracy. . . . . . Modern History of Toxicology. Industrial RevolutionThe Jungle, Wiley Bill1900 -

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Toxicity Testing

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Ecorse Creek 1996 Toxicity Testing

Ecorse Creek 1996 Toxicity Testing. Prepared by: StreamTeam O.L.of Mt. Carmel H.S. in cooperation with the Michigan Department of Environmental Quality (MDEQ). With special contributions from : Southgate Anderson H.S. and RIverview H.S. STREAMTEAM ‘96-’97.

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Toxicity and Field Testing Apparatus

. SA Bill of Rights. 24. Environment Everyone has the right- to an environment that is not harmful to their health or well-being; and to have the environment protected, for the benefit of present and future generations, through reasonable legislative and other measures that- prevent pollution an

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Toxicity Testing in Marine Conservation

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Toxicity Testing cont d

Shape of the Dose-Response Relationship. Why LC50?. . . . Concentration (or Dose). Response. Low. High. 0%. 100%. Acute Toxicity Test Design. Test Material (toxicant)PureCommercial formulationMixtures of known concentrationCarriers/solventsUnknown mixtures (eg. sediment,effluent). 2. Test OrganismMost sensitiveMost representativeWild speciesRear in labKnown physiologyBred for uniformityCertified disease freeKnown susceptible strain.

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Acute and Chronic Toxicity Testing

Acute and Chronic Toxicity Testing. Standard Methods . Multiple methods have been standardized (certified) by multiple organizations American Society for Testing and Materials (ASTM) Organization for Economic Cooperation and Materials (OECD) – (Europe based) National Toxicology Program (NTP)

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Digoxin toxicity

Digoxin toxicity. Alex Battistini. Overview. 1. 2. Pharmacology of digoxin. Clinical Uses. Introduction. Toxicity and management. 3. 4. Introduction. Digitalis: Cardiac glycoside that occurs naturally in plants

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TRACEABILITY IN TOXICITY TESTING

TRACEABILITY IN TOXICITY TESTING. Beth Thompson September 20, 2011 . TRACEABILITY. COMPLETENESS OF THE INFORMATION REGARDING EVERY STEP IN A PROCESS DOCUMENTATION OF RECORDED INFORMATION’S HISTORY GENERATE REPRODUCABLE AND/OR DEFENDABLE DATA. ANALYTICAL TRACEABILITY. SAMPLE TRACKING

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BASICS OF TOXICITY TESTING WITH CERIODAPHNIA DUBIA

BASICS OF TOXICITY TESTING WITH CERIODAPHNIA DUBIA. LAURA SHEALY SHEALY CONSULTING, LLC. TOPICS FOR DISCUSSION. PURPOSE OF TOXICITY TESTING WET TEST PROCEDURES DATA INTERPRETATION. PURPOSE OF WHOLE EFFLUENT TOXICITY. DEFINITION Whole effluent toxicity (WET)

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HURDLES IN TOXICITY TESTING

HURDLES IN TOXICITY TESTING. Elizabeth Thompson Shealy Consulting, LLC 2013 ASP Annual Workshop . TOPICS FOR DISCUSSION. Toxicity Testing Basics Specific Challenges with Ceriodaphnia and Toxicity in General . History.

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Toxicity

Toxicity. By: Andres Robledo. Definition. Toxicity: A measure of how harmful a substance is in causing injury, illness, or death to a living organism depends on several factors. Dose: The amount of a potentially harmful substance an individual ingests, inhales, or absorbs through the skin.

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Toxicity Testing: Nitrification Inhibition

Toxicity Testing: Nitrification Inhibition. Jessica Shaw Environmental Supervisor City of Wenatchee. City of Wenatchee. What happened? . Problems at the POTW NPDES Violations Lawsuit by Environmental Groups 1. High Strength 2. Inhibitory/Toxic Characteristics.

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Chapter 20: Toxicity Testing

Chapter 20: Toxicity Testing. Toxicity Testing. There are two purposes of toxicity testing. There is a quantitative effort to elucidate a dose–effect relationship There is a qualitative determination of the toxicity of the agent relative to other known chemicals. Toxicology testing, cont.

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Toxicity Testing

Toxicity Testing. and Environmental Risk Assessment. Dimensions of the Toxic Chemical Problem. Chemical entities 4-10 million Developed annually ~ 6000 In commerce ~ 65,000 In common use ~ 6,000 Regulated water 129 air 25 .

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The Future of Toxicity Testing in the US

Some Data Interpretation Challenges and Opportunities Implementing the NAS Vision for Toxicity Testing in the 21 st Century ………………………………………………………………. The Future of Toxicity Testing in the US Creating a Roadmap to Implement the NRC Vision and Strategy Washington DC June 21, 2010

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Acute and Chronic Toxicity Testing

Acute and Chronic Toxicity Testing. Standard Methods. Multiple methods have been standardized (certified) by multiple organizations American Society for Testing and Materials (ASTM) Organization for Economic Cooperation and Materials (OECD) – (Europe based) National Toxicology Program (NTP)

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Toxicity Testing II P erforming a toxicity test

Toxicity Testing II P erforming a toxicity test. Toxicity testing. Acute toxicity test Short time frame exposure (96h) “kill ‘em and count ‘em” LC 50 , TLM (median tolerance limit EC 50 (effective concentration) Chronic toxicity test Longer time frame exposure (1 week to 3 years)

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Toxicity testing on animals

Toxicity testing on animals. No Observed Effect Level (NOEL) = Exposure with no adverse effects in animal models. ÷ 10. NOEL for human exposure. Data from case reports and observational studies. Risk assessment -Which adverse effect seen in animals are likely to also affect human health?

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W507 – Dose response and toxicity testing

W507 – Dose response and toxicity testing. “In all things there is a poison, and there is nothing without a poison. It depends only upon the dose whether a poison is poison or not.” Paracelsus (1493 - 1541). Dose response curves.

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Toxicity Testing Services

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MAIN TOXICITY TESTING

MAIN TOXICITY TESTING. TESTING STRATEGIES. A number of different types of data are used in order to establish the safety of chemical substances for use in foods. These include: Consideration of the chemical structutre and any intended biological activity (e.g. anti-oxidant)

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