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National Institute of Allergy and Infectious Diseases

National Institute of Allergy and Infectious Diseases. Review of applications in response to NIAID grant initiatives

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National Institute of Allergy and Infectious Diseases

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  1. National Institute of Allergy and Infectious Diseases Review of applications in response to NIAID grant initiatives Eleazar Cohen, Ph.D. Scientific Review Administrator Division of Extramural Activities, NIAID, NIH, DHHS 6700-B Rockledge Drive, Room 3129, MSC 7616 Bethesda, MD 20892 Phone: (301) 435-3564 Fax: (301) 402-2638 email:  ecohen@niaid.nih.gov

  2. Review of applications in response to NIAID grant initiatives • What is an RFA • How are RFAs developed • Where are RFAs published • Types of research funded through RFAs • Submitting applications in response to RFAs • Review of applications responding to RFAs

  3. What is an RFA? • RFAs are initiatives sponsored by one or more NIH institutes or centers that stimulates research by requesting grant applications in a well-defined scientific area.

  4. Where are RFAs published ? • All RFAs are published in our NIAID web page. http://www.niaid.nih.gov/

  5. How are applications submitted in response to an RFA ? Receipt Date: Applications submitted in response to an NIAID initiative (RFA, PA, etc) are due at the NIAID on the date listed in the RFA. However, the applications must be postmarked by that date when sent to CSR. In most cases RFAs list only one receipt date in a year. However, some RFAs have multiple receipt dates.

  6. How are applications submitted in response to an RFA ? • RFAs sometimes request that applicants send a letter of intent (LOI). However, LOIs are not absolutely required or binding, and do not affect the review of a subsequent application. • NIAID staff use the information in the LOIs to estimate peer review workload and to begin planning for a review.

  7. How are applications submitted in response to an RFA ? Special Requirements RFAs list specific elements, for example: • Program Overview (for U19 or P01 multi-project applications) • Research Plan, Project Goals and Milestones • Scientific and Technical Expertise • Documentation of Experience with Innovative Projects • Special Budget Requests • Specific Format Issues

  8. How are applications submitted in response to an RFA ? Other Special Requirements: • Use of Animals in Research • Human Subjects Protection • Data and Safety Monitoring Plan • Sharing Research Data • Sharing of Model Organisms • Human Embryonic Stem Cells (hESC) • Select Agent Use

  9. How are applications submitted in response to an RFA reviewed ? • Applications submitted in response to RFAs are reviewed by Special Emphasis Panels (SEPs) • A roster for every NIAID RFA is located on the NIH Web page under NIAID Special Emphasis Panels.

  10. How are applications submitted in response to an RFA reviewed ? A typical SEP has members with: • Demonstrated scientific expertise • Mature judgment • Breath of perspective • Diversity of expertises represented • Impartiality • Adequate representation of women and minority scientist

  11. How are applications submitted in response to an RFA reviewed ? Review Criteria • RFAs use the standard NIH five review criteria (Significance, Approach, Innovation, Investigator and Environment ) as the basis for evaluation of the technical and scientific merit of the applications. • RFAs may also have additional criteria to meet the specific needs of the initiative.

  12. How are applications submitted in response to an RFA reviewed ? Instructions to Reviewers Base priority scores ONLY on: • Requirements of the RFA • What is spelled out in the application • The published review criteria • Each application standing alone

  13. How are applications submitted in response to an RFA reviewed ? Benchmarks of an “Outstanding” Grant Application • Responsive to the RFA • New or original idea • Sound rationale for proposed studies • Knowledge of published relevant work • Experience in the essential methodology • Future directions and contingency plans

  14. How are applications submitted in response to an RFA reviewed ? Additional Review Criteria The following items will also be considered in the determination of scientific merit and the priority score: • Protection of Human Subjects from Research Risk • Inclusion of Women, Minorities and Children in Research • Care and Use of Vertebrate Animals in Research

  15. Results of NIAID Peer Review • Scored, Scientific Merit Rating • Streamlined –noncompetitive • Not recommended for further consideration (NRFC) • Deferral- rarely

  16. Results of NIAID Peer Review Reviewers must also consider: • Human Subject Issues (5 areas) • Animal Use Issues • Biohazards _____________________________ • Sharing Model organisms • Sharing Resources, Data

  17. Results of NIAID Peer Review No Effect on Priority Score, Advisory only Budget: • Appropriateness • Justification

  18. Results of NIAID Peer Review • Budget reductions • Deletion of Components • Bars to award: Human/Animal use Biohazards

  19. Results of NIAID Peer Review Summary Statement • Arrives 1-2 months after review • Prepared by SRA • Explains review outcome • Identifies areas for improvement

  20. Review of applications in response to NIAID grant initiatives Questions ?

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