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ADVANCE - post trial O bservatio N al Study Key results

“Hot Topics in Diabetes” 50 th EASD, Vienna 2014. ADVANCE - post trial O bservatio N al Study Key results. BP Arm. BP levels: in-trial and p ost trial ( before and after stopping randomised treatment). Mortality ( Overall follow-up: median of 9.9 years).

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ADVANCE - post trial O bservatio N al Study Key results

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  1. “Hot Topics in Diabetes” 50th EASD, Vienna 2014 • ADVANCE - • post trial ObservatioNal Study • Key results

  2. BP Arm

  3. BP levels: in-trial and post trial(before and after stopping randomised treatment)

  4. Mortality(Overall follow-up: median of 9.9 years)

  5. Major Macrovascular Events (Overall Follow-up: median of 9.9 years)

  6. Effects by Subgroups(all cause mortality: overall follow-up: 9.9 years) P heterogeneity > 0.2 for all

  7. Effects on Mortality (by calendar year)

  8. Hazard ratios and event numbers(All-cause mortality)

  9. Glucose arm

  10. HbA1c levels Any effect observed during ADVANCE-ON is attributable to the glycaemic difference achieved during ADVANCE

  11. Mortality (overall in-trial and post-trial follow-up)

  12. Major Vascular events (overall in-trial and post-trial follow-up)

  13. Microvascular events (overall in-trial and post-trial follow-up)

  14. End-stage kidney disease (overall in-trial and post-trial follow-up)

  15. Effects on Mortality by calendar year

  16. Effects on Vascular Events by calendar year

  17. Effects on Microvascular events by calendar year

  18. Effects by Subgroups (all cause death overall in-trial and post-trial follow-up) P for heterogeneity >0.1

  19. “Hot Topics in Diabetes” 50th EASD, Vienna 2014 • ADVANCE - • post trial ObservatioNal Study • Key results

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