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PHAR 417 Quiz 2 Drs. Abraham and Adams

PHAR 417 Quiz 2 Drs. Abraham and Adams. Question 1. Which enzyme is responsible for the rate limiting step in the biosynthesis of norepinephrine (NE)? Dopamine β -hydroxylase Tyrosine hydroxylase DOPA decarboxylase Monoamine oxidase. Question 2.

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PHAR 417 Quiz 2 Drs. Abraham and Adams

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  1. PHAR 417 Quiz 2Drs. Abraham and Adams

  2. Question 1 Which enzyme is responsible for the rate limiting step in the biosynthesis of norepinephrine (NE)? • Dopamine β-hydroxylase • Tyrosine hydroxylase • DOPA decarboxylase • Monoamine oxidase

  3. Question 2 Termination of the norepinephrine (NE) signal in the synapse is mediated by: • Uptake 1 • Uptake 2 • Diffusion away from the synapse • All of the above

  4. Question 3 Which of the following agents produces the largest diuresis (i.e., which is the most effective diuretic)? • Furosemide (Lasix) • Spironolactone (Aldactone) • Acetazolamide (Diamox) • Hydrochlorothiazide (HydroDiuril)

  5. Question 4 Which of the following structures is a substrate for catechol O-methyl transferase (COMT)? • Norepinephrine • Ephedrine • Albuterol • Terbutaline

  6. Question 5 Which structural feature is a major contributor to the beta receptor blocking activity of propranolol? • The phenolic hydroxyls • The beta hydroxyl • The large hydrophobic aromatic ring • The secondary amine

  7. Question 6 Which of the following hemodynamic factors regulates systemic blood pressure? Sympathetic nerve activity Plasma Renin activity Aldosterone All of the above.

  8. Question 7 Which of the following is NOT a beta receptor antagonist? Metaproterenol (Alupent) Metoprolol (Toprol) Esmolol (Brevibloc) Carvedilol (Coreg)

  9. Question 8 Which of the following is NOT an alpha receptor antagonist? Phenoxybenzamine (Dibenamine) Metoprolol (Toprol) Doxazosin Cardura) Phentolamine (Regitine) Tamsulosin (Flomax)

  10. Question 9 Select the Angiotensin receptor antagonist from the list below. Furosemide (Lasix) Captopril (Capoten) Candesartan (Atacand) Minoxidil (Loniten) Hydrochlorthiazide (Hydro-Diuril)

  11. Question 10 Which of the following does NOT have a vasodilator effect as its major mechanism of action? Prazosin (Minipress) Captopril (Capoten) Candesartan (Atacand) Amiloride (Midamor) Phentolamine (Regitine)

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