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NPC assembly/insertion. Nucleoplasm. Cytoplasm. Ran Gtpase - a molecular switch. OFF. ON. RCC1. GDP. GTP. Ran GTP. Ran GDP. nucleus. cytoplasm. RanGAP. RanBP1. Ran GTP. Ran GDP. Pi. CB21_Hetzer_fig.2. Ran GTP. Ran GTP. NES. NLS. Importin. Ran GDP. Exportin. Ran
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Nucleoplasm Cytoplasm
RCC1 GDP GTP Ran GTP Ran GDP nucleus cytoplasm RanGAP RanBP1 Ran GTP Ran GDP Pi CB21_Hetzer_fig.2
Ran GTP Ran GTP NES NLS Importin Ran GDP Exportin Ran GAP Ran GDP NES NLS Ran BP1 NTF2 NTF2 Exportin Ran GTP Importin cytoplasm ONM INM nucleoplasm NES NLS Ran GDP NTF2 Ran GDP Exportin Importin Ran GTP Ran GTP NTF2 RCC1 RCC1 Ran GTP NES NLS Importin Exportin EXPORT IMPORT CB21_Hetzer_fig.3