Particularities of electrical impedance images in different forms of growth of infiltrative breast cancer.

1. Graz 2007 XIII ICEBI & VIII EIT Particularities of electrical impedance images in different forms of growth of infiltrative breast cancer. N. Sotskova, А. Karpov, М. Korotkova, А. Sentcha Outpatient Department №1 of the Yaroslavl Railway Clinical Hospital attached to the JSC "RZhD", Russia Municipal Clinical Hospital №9, Yaroslavl, Russia

2. Graz 2007 XIII ICEBI & VIII EIT The pathophysiological phases, characterized bythe process of a cancerous.

3. Graz 2007 XIII ICEBI & VIII EIT The purpose of the research was to reveal particularities of the electroimpedance images- in a nodular form of cancer, which lacks such features as edema, inflammation and abnorma-lities of vascularization (noncomplicated breast cancer); - in a nodular form of cancer in combination with the above-mentioned complications (com-plicated breast cancer); - in an edematous-infiltrative form of breast cancer.

4. Graz 2007 XIII ICEBI & VIII EIT Two groups were formed the main group and the reference group: • The main group - 31 patients: • Ia subgroup - 9 patients with noncomplicated breast cancer • Ib subgroup – 18 patients with complicated breast cancer • Ic subgroup – 4 patients with edematous-infiltrative form of breast cancer • The reference group - 102 healthy women

5. Graz 2007 XIII ICEBI & VIII EIT Assessment of the mammary gland electrical impedance images. I. Image II. Measurement

6. Graz 2007 XIII ICEBI & VIII EIT The noncomplicated nodular form of breast cancer (subgroup Ia). Image Focal lesions were differenti- ated in 100% cases of the tu- mour site, taking form of a hypoimpedance area in seve- ral scanning planes (with the electroconductivity index >0,95) .

7. Graz 2007 XIII ICEBI & VIII EIT The noncomplicated nodular form of breast cancer (subgroup Ia). Measurement

8. Graz 2007 XIII ICEBI & VIII EIT The noncomplicated nodular form of breast cancer (subgroup Ia).

9. Graz 2007 XIII ICEBI & VIII EIT The noncomplicated nodular form of breast cancer (subgroup Ia).

10. Graz 2007 XIII ICEBI & VIII EIT The noncomplicated nodular form of breast cancer (subgroup Ia).

11. Graz 2007 XIII ICEBI & VIII EIT The noncomplicated nodular form of breast cancer (subgroup Ia).

12. Graz 2007 XIII ICEBI & VIII EIT The nodular form of breast cancer, involving edema, infiltration or abnormalities of vascularization (subgroup 1b). Anatomic changes and displacement of the breast internal structures were revealed in 78% of the cases. The hypoimpedance area with the electroconductivity index >0,95, typical for the NBC, was absent in 78% of the cases. An hyperimpedance contour on the tumour border with the sur- rounding tissue – in 94% of the cases.

13. Graz 2007 XIII ICEBI & VIII EIT The nodular form of breast cancer, involving edema, infiltration or abnormalities of vascularization (subgroup 1b). Measurement

14. Graz 2007 XIII ICEBI & VIII EIT The nodular form of breast cancer, involving edema, infiltration or abnormalities of vascularization (subgroup 1b).

15. Graz 2007 XIII ICEBI & VIII EIT The nodular form of breast cancer, involving edema, infiltration or abnormalities of vascularization (subgroup 1b).

16. Graz 2007 XIII ICEBI & VIII EIT The nodular form of breast cancer, involving edema, infiltration or abnormalities of vascularization (subgroup 1b).

17. Graz 2007 XIII ICEBI & VIII EIT The nodular form of breast cancer, involving edema, infiltration or abnormalities of vascularization (subgroup 1b).

18. Graz 2007 XIII ICEBI & VIII EIT Edematous-infiltrative form of breast cancer (subgroup Ic). Image In 100% of the cases there were hypoimpedance areas with the electrical conductivity index >0,95. Massive hyperimpedance of the affected breast was obvious in 100% of the cases

19. Graz 2007 XIII ICEBI & VIII EIT Edematous-infiltrative form of breast cancer (subgroup Ic). Measurement

20. Graz 2007 XIII ICEBI & VIII EIT Edematous-infiltrative form of breast cancer (subgroup Ic).

21. Graz 2007 XIII ICEBI & VIII EIT Edematous-infiltrative form of breast cancer (subgroup Ic).

22. Graz 2007 XIII ICEBI & VIII EIT Edematous-infiltrative form of breast cancer (subgroup Ic).

23. Graz 2007 XIII ICEBI & VIII EIT Edematous-infiltrative form of breast cancer (subgroup Ic).

24. Graz 2007 XIII ICEBI & VIII EIT Edematous-infiltrative form of breast cancer (subgroup Ic).

25. Graz 2007 XIII ICEBI & VIII EIT Visual and quantitative assessment data of the electroimpedance image of the patients’ breasts from the main and the reference groups. * - reliability of discrepancy between this data and the data of the previous column p<0,05; ** - reliability of discrepancy between this data and the data of the previous column p< 0,001

26. Graz 2007 XIII ICEBI & VIII EIT 1. The revealed particularities of the electroimpedance image during various forms of the infiltrating breast cancer growth correlate with the pathophysiological phases of the tumour development. 2. It is primary important for diagnostics to detect noncomplicated forms of the diseases, characterized by high electroconductivity index of malignant cells as well as complicated forms, characterized by high local and total impedance.3. High electroconductivity index and absence of the surrounding tissue reaction are key signs of noncomplicated forms of breast cancer on electroimpedance images. 4. Other criteria should be used for diagnostics of the infiltrating breast cancer, accompanied by edema, inflammation, abnormalities of vascularization, namely, changes of the breast contour, displacement of its internal structures, perifocal infiltration, etc. Conclusions