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Brittle N 1 , Mant J 2 , McManus R 1 , Lasserson D 3 , Sackley C 1

Are TIAs as transient as the name suggests?. Brittle N 1 , Mant J 2 , McManus R 1 , Lasserson D 3 , Sackley C 1. Background. Annual incidence of probable and definite TIA, per thousand = 1.08 (0.95–1.21), standardised to the 2005 population of England (Giles & Rothwell 2007).

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Brittle N 1 , Mant J 2 , McManus R 1 , Lasserson D 3 , Sackley C 1

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  1. Are TIAs as transient as the name suggests? Brittle N1, Mant J2, McManus R1, Lasserson D3, Sackley C1

  2. Background • Annual incidence of probable and definite TIA, per thousand = 1.08 (0.95–1.21), standardised to the 2005 population of England (Giles & Rothwell 2007). • National stroke guidelines recommend that people with a suspected TIA are referred to TIA clinics and managed according to their risk of further stroke. • By definition the neurological symptoms associated with Transient Ischemic Attack (TIA), should persist for no longer than 24 hours. • Little is known about the long term impact of TIA on patient reported outcomes.

  3. Objectives i) To investigate whether patients have depressed mood, and/or residual functional or cognitive problems that adversely influence their day to day living, after being diagnosed with TIA? ii) To investigate the economic impact of TIA on the NHS • where is money best spent to maximise patient outcomes? iii) To inform future trial design by providing information such as the suitability of outcome measures.

  4. Methodology Design: Prospective cohort study Recruitment: • TIA clinics: TIA diagnosis (group A) or TIA “mimic” (Group B) • GP practices: Age/gender/postcode/deprivation matched controls (Group C) We aim to recruit 600 people (200 in each group) over a 12month period.

  5. Data collection: • Baseline data • Questionnaire (demographics, social history, past medical history) • Clinic data collection form for groups A & B (details of presenting condition, investigations and medical management) • Outcome data • Questionnaire at 0, 3, 6 and 12 months (function, anxiety, depression, service use and CV Risk factors) • face-to-face cognitive screen at 0 and 12 months.

  6. Progress to date • The study has been given favourable ethical approval by BEN REC • All study wide checks have been undertaken by the lead R&D office (BBC CLRN) • Study is eligible to be included in the NIHR Clinical Research Network (CRN) Portfolio • Study is in process of being reviewed for adoption by SRN and PCRN • Site specific assessments are underway at collaborating NHS sites

  7. Contact details Nicola Brittle Study Coordinator/PhD student Primary Care Clinical Sciences Department School of Health and Population Sciences University of Birmingham Edgbaston campus Birmingham B15 2TT Tel. 0121 414 5483 Email: n.brittle@bham.ac.uk

  8. Thank you

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