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NIHR Programme Grants for Applied Research Professor Adrian Grant Programme Director

NIHR Dementia Research Workshop. NIHR Programme Grants for Applied Research Professor Adrian Grant Programme Director. 14 January 2011. Programme Grants. Support programmes of research rather than individual studies

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NIHR Programme Grants for Applied Research Professor Adrian Grant Programme Director

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  1. NIHR Dementia Research Workshop NIHR Programme Grants for Applied Research Professor Adrian Grant Programme Director 14 January 2011

  2. Programme Grants • Support programmes of research rather than individual studies • Individual awards for a maximum of £2m over up to five years (average of no more than £400k per year) • Funding is made to an NHS Organisation in England working in collaboration with appropriate academic partners • Two-stage assessment process • Applications and post-award processes managed by team at the NIHR Central Commissioning Facility (NIHR CCF) Background

  3. Programme Grants • Support top quality, collaborative, multidisciplinary teams • ‘Downstream’, applied research • Collection of inter-related research activities • Coherent ‘stream’ of work, where the whole is greater than sum of the individual parts • Often presented as workpackages, subdivided into discrete activities Purpose

  4. Programme Grants • Dementia care in the community Prof Steve Iliffe, Central & North West London NHS Foundation Trust • Support at home through psychological and social interventions Prof Martin Orrell, North East London NHS Foundation Trust • Optimizing care in care homes Prof Clive Ballard, Oxfordshire & Buckinghamshire Mental Health NHS Foundation Trust • Managing challenging behaviour in dementia Prof Esme Moniz-Cook, Humber Mental Health Teaching NHS Trust • Preventing acute confusional illness Prof John Young, Bradford Teaching Hospitals NHS Foundation Trust Some currently funded programmes:

  5. Programme Grants • Track record and appropriate mix of skills • Relevance to priorities and needs of the NHS • Likelihood of significant benefit to patients and the NHS within 3-5 years of programme’s end • Quality of the proposed research • Value for money Patient and Public Involvement given particular attention Selection criteria

  6. Programme Grants • Fuller details are on the website: www.pgfar.nihr.ac.uk • Enquires are welcomed: The Programme Grants stand in the market place E-mail: programme.grants@nihr-ccf.org.uk Telephone: 020 8843 8039 Address: NIHR CCF Grange House 15 Church Street Twickenham, TW1 3NL Further information

  7. NIHR Dementia Research Workshop NIHR Research for Patient Benefit Professor David Armstrong Programme Director 14 January 2011

  8. The RfPB Programme • Response-mode funding programme with a budget of £25m per year • Project grants may be: • Up to 36 months in duration • Up to £250k • Three competitions per year • National Programme with ten Regional Funding Committees • Open to researchers in the NHS in England

  9. The RfPB Programme • Supports high quality investigator-led research projects which have a clear trajectory into patient benefit • Includes qualitative or quantitative research which: • Studies the way the NHS services are provided and used • Evaluates whether interventions are effective and provide value for money • Supports pilot or feasibility studies leading to major applications to other NIHR funding streams

  10. The Application Process • One stage application process • Preliminary scrutiny and administrative sift • External peer and lay review • Full assessment by one of ten regional funding committees • Final ratification • Notification of outcome

  11. The Scrutiny Stage Three questions will be asked: • Is the proposal likely to lead to patient benefit? • Is the presentation and/or methods appropriate for the research question? • Is the application form completed according to the instructions described in the guidance?

  12. Research for Patient BenefitSpend across health category(2009-2010) Cancer 7% Generic Health Relevance 15% Stroke 6% Mental Health 19% Reproductive 8% Oral & Gastro 7% Neurological 6%

  13. Research for Patient Benefit Dementia call • Essentially will use existing processes (Scrutiny Committee, scientific and lay review, Regional Funding Committee appraisal) • Will alert all Regional Committees of the Call and advise them of the strategic need to fund applications in this area, subject to quality thresholds • Will participate with other Programmes in cross-referring applications

  14. For more information, visit www.rfpb.nihr.ac.uk • Or call the RfPB helpline 0208 843 8057

  15. NIHR Dementia Research Workshop NIHR Evaluation Trials and Studies Programmes Professor Tom Walley, CBE Director: NIHR Evaluation Trials and Studies 14 January 2011

  16. DIFFUSION INVENTION EVALUATION ADOPTION Centre for Evidence-based Purchasing NHS Purchasing & Supplies Agency Basic Research Development Pathway Funding MRC Efficacy & Mechanism Evaluation Invention for Innovation Biomedical Research Centres This pathway covers the full range of interventions - pharmaceuticals, biologicals, biotechnologies, procedures, therapies and practices - for the full range of health and health care delivery - prevention, detection, diagnosis, prognosis, treatment, care. Biomedical Research Units Patient Safety and QualityResearch Centres Research for Innovation,Speculation & Creativity Research for Patient Benefit Health Services Research National Institutefor Health Research Programme Grants forApplied Research Public Health Research Service Delivery & Organisation Health Technology Assessment Collabs for Ldrshp in Appl Hlth Res and Care Ctr for Reviews & Dissemination, Cochrane, TARs National Institute for Health & Clinical Excellence Guidance on Health & Healthcare NHS Evidence Access to Evidence NHS Institute for Innovation & Improvement Support for the NHS Strategic Health Authorities Duty of Innovation PrimaryCare Trusts Healthcare Commissioning NHS Providers Patient Care

  17. NIHR Evaluation, Trials and Studies (NETS) programmes Service Delivery & Organisation Established: 1999 Health Services Research Established: 2008 NETSCC: Established: 2008 SDO HSR Public Health Research Established: 2008 Health Technology Assessment Established: 1993 PHR HTA EME Efficacy and Mechanism Evaluation Funded by the MRC Managed by NIHR Established: 2008

  18. Efficacy and Mechanism Evaluation programme Purpose and Remit The EME programme is aimed at supporting ‘science driven’ studies with an expectation of substantial health gain. The EME programme works seamlessly with and sits between MRC programmes and the HTA programme Types of Research Who defines the question? Frequency Per year EME Primary Research addressing efficacy +/- mechanism Continuous with 3 submission deadlines Researcher-led Researcher

  19. NIHR Health Technology Assessment programme Purpose and Remit To deliver information about the effectiveness, costs and broader impact of healthcare treatments and tests for those who plan, provide or receive care in the NHS. Types of Research Who defines the question? Frequency Per year Primary research Feasibility & pilot Evidence synthesis HTA programme 4 calls Commissioned Primary research Feasibility & pilot Evidence synthesis Continuous with 4 closing dates Clinical evaluation Researcher HTA Researcher Led Theme from HTA programme Question from researcher ThemedCalls Primary research Evidence synthesis 1 call NICE Guidance Specific technology assessment Direct referral to On-contract teams NICE

  20. HTA Studies currently underway in dementia • Reminiscence groups for people with dementia and their family care-givers Professor R Woods, University of Wales 2007-11 £1,536,391 • HTA study of antidepressants for depression in dementia (HTA-SADD) Professor S Banerjee The Institute of Psychiatry, 2006-11 £2,210,588 • Individual Cognitive Stimulation Therapy for dementia (iCST Trial) Professor Martin Orrell, UCL, 2010-14 £1,213,646

  21. HTA Studies currently underway in dementia • Effectiveness and cost effectiveness of Collaborative cARE for people with DEMentia in primary care (CARE-DEM trial) Professor S Iliffe, UCL 2010-15 £2,315,251 • The START (STrAtegies for RelaTives) study: to determine the effectiveness of a manual based coping strategy programme in promoting the mental health of carers of people with dementia Professor G Livingston UCL 2009-13 £1,521,781

  22. NIHR Service Delivery and Organisation Programme Purpose and Remit Produces research about the organisation and delivery of healthcare for NHS leaders and decision-makers, commissioners, providers of health care, partner organisations such as local authorities and the voluntary sector, and for users of health care. This evidence is intended to improve practice in relation to the organisation and delivery of healthcare. Types of Research Who defines the question? Primary research Evidence synthesis Empirical studies SDO programme Priority Areas Commissioned SDO NHS SDO programme Researcher Primary research Evidence synthesis Evaluations NHS Evaluations Researcher-led Primary research Evidence synthesis SDO Studies Researcher

  23. SDO Studies currently underway in dementia • Better mental health care for older people in general hospitals Professor J Gladman, Nottingham 2008-11 £473,487

  24. NIHR Public Health Research programme Purpose and Remit The PHR programmeevaluates public health interventions, providing new knowledge on the benefits, costs, acceptability and wider impacts of non-NHS interventions intended to improve the health of the public and reduce inequalities in health. The scope of the programme is multi-disciplinary and broad covering a range of public health interventions. Types of Research Who defines the question? Frequency Per year Non-NHS Primary research Evidence synthesis As required PHR programme Non-NHS Primary research Evidence synthesis Continuous with 3 closing dates Researcher Commissioned PHR Researcher-led

  25. NIHR Health Services Research programme Purpose and Remit The HSR programme funds research to improve the quality, effectiveness and accessibility of the NHS. The HSR programme addresses the three dimensions of quality currently of central concern to the NHS: patient safety, patient experience and effectiveness of care. Types of Research Who defines the question? Frequency Per year Any study design Researcher-led Researcher Twice yearly HSR

  26. NETS as a system Facilitating researchers, speeding review Transfers between NETS programmes Active collaboration between programmes Directors' meetings Joint calls Meeting with networks SDO HSR PHR HTA EME

  27. Keele Keele Support for CTUs 25 (in England) now supported by HTA programme “pump-priming”

  28. Major new opportunity for funding research into dementia • NETS programmes focused on projects with national reach • Multicentred • Trials and other designs (Engaging with CTUs)

  29. NIHR Dementia Research Workshop For further information, please visit: www.nihr.ac.uk/research/Pages/Dementia.aspx 14 January 2011

  30. National Institute for Health ResearchDementia Research Workshop 14 January 2011

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