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Doxazosin (Cardura (Pfizer))

The mean weight of normal prostate in adult male is about 11 gram (usually ranging between 7 & 16 gram). Some references state that the avarage weight is 2O – 25 grams. The prostate measures 1.6 x 1 x 1.2 inches.

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Doxazosin (Cardura (Pfizer))

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  1. The mean weight of normal prostate in adult male is about 11 gram (usually ranging between 7 & 16 gram). Some references state that the avarage weight is 2O – 25 grams. The prostate measures 1.6 x 1 x 1.2 inches. • The prostatic fluid is expelled in with spermatozoa in the first ejaculation fraction. • The female Para urethral glands or Skene’s glands were officially renamed the female prostate. The female prostate like male prostate secrets PSA . The level of this antigen rise in the presence of carcinoma of the gland. • The drugs used for treatment of prostatic hyperplasia: • 1. Drugs which inhibits 5 alpha reductase: finastride & epistride.( Andriole et al. J. Urol 172:1339, 2OO4) • 2. Alpha 1- adrenoreceptors : e.g. tamasulosin,Doxazosin (Cardura), prazosin. Afluzosin, indoramin, terazosin.. This group causes relaxation of smooth muscle in prostate & helps to relieve obstruction It must be continued to be effective. (Auffenberg, G. B. et al, Urol clin North Am. 36: 443, 2OO9)

  2. Doxazosin (Cardura (Pfizer)) • It is approved by FDA for treatment of benign prostatic hyperplasia.It is alpha 1 adrenergic receptor blocker that inhibit nor epinephrine to the alpha 1 receptors on the membrane of vascular smooth muscle cells. • In Egypt tablet formulation sold as Duracin produced by Biopharm group for research & drug industry, Dosin by Epico & Doxazocine by multi - Apex.

  3. Prostanorm capsule • Each capsule contains : • @ Saw palmetto berry extract 15O mg • @ Pygeum extract 564 mg • @ Stinging nettle extract 1O mg • @ Zinc gluconate 55 mg • The mechanism of action of saw palmetto, pygeum, stinging nettle is related to their combined ability in inhibition of dihydro testosterone binding in both the cystolic & nuclear androgen receptors, inhibition of 5 alpha reductase & interference with estrogen receptors.

  4. Produced in Egypt by october pharma .Each capsule contain : Pygeum africanum 5O mg extract It is prepared from the park of the tree. It is moderately improve urinary symptoms of the prostate gland. It reduces urinary hesitancy , the number of times patient needs to wake at night to urinate & pain during urination. It DOES NOT reduce the size of prostate gland or reverse the process of BPH. It is not clear how pegeum compares to the effectiveness of drugs as alpha adregenic blockers or 5-alpha reductase inhibtors or herbal supplement as saw palmetto. In the market, there are a lot of different herbal treatment by different pharmaceutical companies with different trade names but there is no FDA review or approval. Prostacure capsuleHerbal treatment not FDA reviewed or approved

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