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ENHANCED MS WITH THE TURN OF KEY. Introducing ionKey/MS. What does ionKey/MS™ deliver? 2-40x sensitivity vs. your current MS UPLC ® performance and reliability Standardization and consistency Flexibility . In Search of a Step Change in Sensitivity? .
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Introducing ionKey/MS • What does ionKey/MS™ deliver? • 2-40x sensitivity vs. your current MS • UPLC® performance and reliability • Standardization and consistency • Flexibility
Xevo® TQ-SA Step Change in Sensitivity Maximizing signal Maximizing robustness
Xevo TQ-SA Step Change in Sensitivity Xevo TQ-S Enhanced sensitivity >25X increase in peak area>5X increase in signal:noise Relative ion abundance Xevo TQ Reserpine (50fg) UPLC/MRM
Where to Next? 75µm ID 150µm ID 300µm ID + Fast and Sensitive Useable routinely Very Sensitive Flow rates too low for routine use Very Fast Marginal sensitivity increase 0
PLUG AND PLAY MORE SENSITIVITY UPLC PERFORMANCE YOU KNOW ROBUST REPRODUCIBLE RELIABLE THE FUTURE OF MS
PLUG AND PLAY MORE SENSITIVITY UPLC PERFORMANCE YOU KNOW ROBUST REPRODUCIBLE RELIABLE THE FUTURE OF MS
More Sensitivity Standard 2.1mm column ionKey/MS 20X Increase
More Sensitivity ionKey/MS 2Fold suppression in signal due to Matrix Effects 2.1mm 24Fold suppression in signal due to Matrix Effects ionKey/MS Standard Flow LC-MS
PLUG AND PLAY MORE SENSITIVITY UPLC PERFORMANCE YOU KNOW ROBUST REPRODUCIBLE RELIABLE THE FUTURE OF MS
PLUG AND PLAY MORE SENSITIVITY UPLC PERFORMANCE YOU KNOW ROBUST REPRODUCIBLE RELIABLE THE FUTURE OF MS
Capillary scale UPLC can be challenging Reproducibility Robustness User Expertise Requirement Applicability to Routine Sensitivity
ionKey/MS is Plug and Play • ENHANCED MS WITH THE TURN OF KEY
PLUG AND PLAY MORE SENSITIVITY UPLC PERFORMANCE YOU KNOW ROBUST REPRODUCIBLE RELIABLE THE FUTURE OF MS
Robust, Reliable Reproducible Reproducibility of the same compound over: Retention Time Reproducibility 15 QCs over 500 crashed plasma injections 5 Users 5 Systems 18 iKeys 1.64% RSD
Validated Assay Teriparadite (Forteo®) Avg MWT 4117.7
PLUG AND PLAY MORE SENSITIVITY UPLC PERFORMANCE YOU KNOW ROBUST REPRODUCIBLE RELIABLE THE FUTURE OF MS
The Future of MS Already over 25 publications and presentations in leading scientific journals and conferences such as: Journal of Chromatography, Bioanalysis Journal, Journal of Proteomics, ASMS, HPLC, EBF CPSA, and more.