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Understanding Cystic Fibrosis-Related Infertility in Men and Women

Discover the impact of cystic fibrosis on male and female fertility, covering causes, challenges, and available resources. Learn about congenital bilateral absence of vas deferens in men and cervical mucus thickness in women. Resources provided for further exploration.

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Understanding Cystic Fibrosis-Related Infertility in Men and Women

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  1. Cystic FibrosisInfertility in Men and Women Mary Goodman March 15, 2006

  2. Infertility in Males • Although men with Cystic Fibrosis still may have a great sex life, the majority of them are infertile. • 99% of adult males with Cystic Fibrosis are characterized by congenital bilateral absence of vas deferens (CBAVD).

  3. CBVAD • Congenital bilateral absence of the vas deferens • The improper development of the tube through which sperm are released from the testes. • Similar to being born with a vasectomy; you have sperm but pathway to release them is missing. • Causes of CBVAD are genetic mutations and variations in the CF gene.

  4. Female Infertility • Females with CF are less fertile than normal healthy women. • Delayed puberty and amenorrhoea are common due to malnutrition. • Women with CF have a thicker cervical mucus which makes it hard for the sperm to swim through, however not impossible.

  5. Resources • Jarzabek K, Zbucka M, Pepinski W, Szamatowicx J, Domitrz J, Janica J, Wolczynoski S, Szamatoqicz M. 2004. Cystic Fibrosis as a cause of infertility. Reproductive Biology. Vol. 4, No. 2. • www.cysticfibrosismedicine.com • www.healingwell.com/library/cysticfibrosis/info1.asp • www.dnadirect.com/resource/conditions/cystic_fibrosis/faqs_CF_infertility.jsp

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