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Mechanical factors in the initiation and fate of atherosclerotic plaques

Mechanical factors in the initiation and fate of atherosclerotic plaques. Peter D Weinberg Department of Bioengineering Imperial College London. Flow. J R A Mitchell, C J Schwartz. Arterial Disease , 1965. Flow. J R A Mitchell, C J Schwartz. Arterial Disease , 1965

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Mechanical factors in the initiation and fate of atherosclerotic plaques

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  1. Mechanical factors in the initiation and fate of atherosclerotic plaques Peter D Weinberg Department of Bioengineering Imperial College London

  2. Flow J R A Mitchell, C J Schwartz. Arterial Disease, 1965

  3. Flow J R A Mitchell, C J Schwartz. Arterial Disease, 1965 CG Caro et al, Proc R Soc Lond B 1971;177:109-159

  4. Flow Nicolai Anitschkow (1885-1964) N Anitschkow. In: Arteriosclerosis (E V Cowdry, ed), 1933.

  5. Flow J B Somer, C J Schwartz. Atherosclerosis 1971;13:293-304.

  6. Insudation theory of Anitschkow There is a continuous movement of plasma constituents from lumen to adventitia “Lipoids” in this flow precipitate by interaction with the ground substance of the wall Lymphocytes or monocytes enter the wall and ingest lipoid, becoming foam cells Process occurs faster where there is a greater transport across the wall N Anitschkow. In: Arteriosclerosis (E V Cowdry, ed), 1933.

  7. Flow S E Barnes, P D Weinberg.Arterioscler Thromb Vasc Biol 1998;18:300-308

  8. Mature Immature Flow S E Barnes, P D Weinberg.Arterioscler Thromb Vasc Biol 1999;19:2376-2386.

  9. A Sebkhi, P D Weinberg. Atherosclerosis 1994;106:1-8.

  10. H Sinzinger et al. Blood Vessels 1980; 17: 44-52 R C Schroter, unpublished

  11. Flow P D Weinberg Biorheology 2002;39:533-537 Pictures from R C Schroter, G D Sloop, J R A Mitchell & C J Schwartz

  12. A Sebkhi, P D Weinberg. Arterioscler Thromb Vasc Biol 1996;16:317-327.

  13. B A Forster, P D Weinberg. Arterioscler Thromb Vasc Biol 1997;17:1361-1368.

  14. ( Downstream - upstream / mean ) x 100% T J Staughton, M J Lever, P D Weinberg. Am J Physiol 2001;281:H53-H59.

  15. 0.2 mm Al-Musawi, Bishton, Dean, Williams, Cremers, Weinberg. Atherosclerosis 2004;72:79

  16. A Kazakidi, S J Sherwin, P D Weinberg, unpublished data

  17. Roach MR, Fletcher J. Atherosclerosis. 1976;24:327-33.

  18. control control Flow control cuff cuff Thubrikar MJ, Baker JW, Nolan SP. Arteriosclerosis. 1988;8:410-20.

  19. Cheng, C. et al. Circulation 2006;113:2744-2753

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